Targeting insulin-like growth factor pathways

被引：88
|
作者：
Yee, D [1 ]
机构：
[1] Univ Minnesota, Ctr Canc, Dept Med, Minneapolis, MN 55455 USA
来源：
BRITISH JOURNAL OF CANCER | 2006年 / 94卷 / 04期
关键词：
insulin-like growth factors; insulin-like growth factor receptors; monoclonal antibodies; tyrosine kinase inhibitors;
D O I：
10.1038/sj.bjc.6602963
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Some cancer cells depend on the function of specific molecules for their growth, survival, and metastatic potential. Targeting of these critical molecules has arguably been the best therapy for cancer as demonstrated by the success of tamoxifen and trastuzumab in breast cancer. This review will evaluate the type IIGF receptor (IGF-IR) as a potential target for cancer therapy. As new drugs come forward targeting this receptor system, several issues will need to be addressed in the early clinical trials using these agents.
引用
收藏
页码：465 / 468
页数：4
相关论文
共 50 条
  • [41] Insulin-like growth factor-binding proteins and bone metabolism
    Conover, Cheryl A.
    AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2008, 294 (01): : E10 - E14
  • [42] Insulin-like growth factor-binding proteins and ovarian folliculogenesis
    Monget, P
    Besnard, N
    Huet, C
    Pisselet, C
    Monniaux, D
    HORMONE RESEARCH, 1996, 45 (3-5) : 211 - 217
  • [43] Insulin-like growth factor II in gynecological cancers: A preliminary study
    Mathur, SP
    Landen, CP
    Datta, SM
    Hoffman, MC
    Mathur, RS
    Young, RC
    AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2003, 49 (02) : 113 - 119
  • [44] Biological roles of insulin-like growth factor binding proteins (IGFBPs)
    Ho-Seong Kim
    Ron G Rosenfeld
    Youngman Oh
    Experimental & Molecular Medicine, 1997, 29 : 85 - 96
  • [45] EXPRESSION OF INSULIN-LIKE GROWTH-FACTOR IN ADULT AND EMBRYONIC KIDNEY
    HAMMERMAN, MR
    RYAN, G
    MILLER, SB
    MINERAL AND ELECTROLYTE METABOLISM, 1992, 18 (2-5) : 253 - 255
  • [46] The Insulin-Like Growth Factor System in Bone Basic and Clinical Implications
    Kawai, Masanobu
    Rosen, Clifford J.
    ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 2012, 41 (02) : 323 - +
  • [47] Biological roles of insulin-like growth factor binding proteins (IGFBPs)
    Kim, HS
    Rosenfeld, RG
    Oh, YM
    EXPERIMENTAL AND MOLECULAR MEDICINE, 1997, 29 (02): : 85 - 96
  • [48] Levels of insulin-like growth factor after stem cell transplantation
    Munker, R
    Salat, C
    Pihusch, R
    Diem, H
    Hiller, E
    Glass, J
    Kolb, HJ
    Yu, H
    EUROPEAN JOURNAL OF MEDICAL RESEARCH, 2001, 6 (04) : 181 - 184
  • [49] Insulin-like growth factor-I, insulin-like growth factor binding protein-3 and risk of benign prostate hyperplasia in the prostate cancer prevention trial
    Neuhouser, Marian L.
    Schenk, Jeannette
    Song, Yoon Ju
    Tangen, Catherine M.
    Goodman, Phyllis J.
    Pollak, Michael
    Penson, David F.
    Thompson, Ian M.
    Kristal, Alan R.
    PROSTATE, 2008, 68 (13): : 1477 - 1486
  • [50] Cerebrospinal fluid insulin-like growth factor (IGF-1) and insulin-like growth factor binding protein (IGFBP-2) in children with acute lymphoblastic leukemia
    Riikonen, R
    Vettenranta, K
    Riikonen, P
    Turpeinen, U
    Saarinen-Pihkala, UM
    PEDIATRIC BLOOD & CANCER, 2004, 43 (02) : 110 - 114
12345