Targeting insulin-like growth factor pathways

被引：88
|
作者：
Yee, D [1 ]
机构：
[1] Univ Minnesota, Ctr Canc, Dept Med, Minneapolis, MN 55455 USA
来源：
BRITISH JOURNAL OF CANCER | 2006年 / 94卷 / 04期
关键词：
insulin-like growth factors; insulin-like growth factor receptors; monoclonal antibodies; tyrosine kinase inhibitors;
D O I：
10.1038/sj.bjc.6602963
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Some cancer cells depend on the function of specific molecules for their growth, survival, and metastatic potential. Targeting of these critical molecules has arguably been the best therapy for cancer as demonstrated by the success of tamoxifen and trastuzumab in breast cancer. This review will evaluate the type IIGF receptor (IGF-IR) as a potential target for cancer therapy. As new drugs come forward targeting this receptor system, several issues will need to be addressed in the early clinical trials using these agents.
引用
收藏
页码：465 / 468
页数：4
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