Dose finding of 3′deoxyadenosine and deoxycoformycin for the treatment of Trypanosoma evansi infection: An effective and nontoxic dose

被引：14
作者：
Dalla Rosa, Luciana [1 ]
Da Silva, Aleksandro S. [2 ]
Oliveira, Camila B. [1 ]
Gressler, Lucas T. [1 ]
Arnold, Caroline B. [1 ]
Baldissera, Matheus D. [1 ]
Sagrillo, Michele [3 ]
Sangoi, Manuela [1 ]
Moresco, Rafael [1 ]
Mendes, Ricardo E.
Weiss, Paulo E. [2 ]
Miletti, Luiz C. [2 ]
Monteiro, Silvia G. [1 ]
机构：
[1] Univ Fed Santa Maria, Santa Maria, RS, Brazil
[2] Univ Estado Santa Catarina UDESC, Florianopolis, SC, Brazil
[3] UNIFRA, Ctr Univ Franciscano, Santa Maria, RS, Brazil
来源：
MICROBIAL PATHOGENESIS | 2015年 / 85卷
关键词：
Adenosine; Trypanosomiasis; Toxicity; Cordycepin; Pentostatin; ADENOSINE-DEAMINASE; AFRICAN TRYPANOSOMIASIS; COLORIMETRIC ASSAY; CELLULAR GROWTH; IN-VIVO; CORDYCEPIN; DNA; TOXICITY; 2-DEOXYCOFORMYCIN; 3'-DEOXYADENOSINE;
D O I：
10.1016/j.micpath.2015.05.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The aim of this study was to evaluate the therapeutic efficacy and safety of using 3'deoxyadenosine (Cordycepin adenosine analogue) combined with deoxycoformycin (Pentostatin an adenosine deaminase inhibitor) in mice infected with Trypanosoma evansi. We show that the combination of Cordycepin (2.0 mg kg(-1)) and Pentostatin (0.2, 0.5, 1.0, 2.0 mg kg(-1)) is effective in the clearance of T. evansi, although at the higher concentrations of Pentostatin 2 mg kg(-1) some toxicity was observed in the liver and kidney. Since the Cordycepin 2.0 mg kg(-1) and Pentostatin 0.2 mg kg(-1) combination was effective and had low toxicity, we recommend this as a therapeutic option for a T evansi mouse model. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：21 / 28
页数：8
相关论文
共 40 条
  • [1] ADENOSINE DEAMINASE FROM HUMAN ERYTHROCYTES - PURIFICATION AND EFFECTS OF ADENOSINE-ANALOGS
    AGARWAL, RP
    SAGAR, SM
    PARKS, RE
    [J]. BIOCHEMICAL PHARMACOLOGY, 1975, 24 (06) : 693 - 701
  • [2] INHIBITORS OF ADENOSINE-DEAMINASE
    AGARWAL, RP
    [J]. PHARMACOLOGY & THERAPEUTICS, 1982, 17 (03) : 399 - 429
  • [3] PicoGreen quantitation of DNA: Effective evaluation of samples pre- or post-PCR
    Ahn, SJ
    Costa, J
    Emanuel, JR
    [J]. NUCLEIC ACIDS RESEARCH, 1996, 24 (13) : 2623 - 2625
  • [4] The ferric reducing ability of plasma (FRAP) as a measure of ''antioxidant power'': The FRAP assay
    Benzie, IFF
    Strain, JJ
    [J]. ANALYTICAL BIOCHEMISTRY, 1996, 239 (01) : 70 - 76
  • [5] Colpo Cristina Braccini, 2005, Cienc. Rural, V35, P717, DOI 10.1590/S0103-84782005000300038
  • [6] Diminazene aceturate in the control of Trypanosoma evansi infection in cats
    Da Silva, A. S.
    Zanette, R. A.
    Wolkmer, P.
    Costa, M. M.
    Garcia, H. A.
    Lopes, S. T. A.
    Santurio, J. M.
    Teixeira, M. M. G.
    Monteiro, S. G.
    [J]. VETERINARY PARASITOLOGY, 2009, 165 (1-2) : 47 - 50
  • [7] Cordycepin (3′-deoxyadenosine) pentostatin (deoxycoformycin) combination treatment of mice experimentally infected with Trypanosoma evansi
    Dalla Rosa, Luciana
    Da Silva, Aleksandro S.
    Gressler, Lucas T.
    Oliveira, Camila B.
    Dambros, Maria G. C.
    Miletti, Luiz C.
    Franca, Raqueli T.
    Lopes, Sonia T. A.
    Samara, Yasmin N.
    Da Veiga, Marcelo L.
    Monteiro, Silvia G.
    [J]. PARASITOLOGY, 2013, 140 (05) : 663 - 671
  • [8] Trypanosoma evansi and Surra: A Review and Perspectives on Transmission, Epidemiology and Control, Impact, and Zoonotic Aspects
    Desquesnes, Marc
    Dargantes, Alan
    Lai, De-Hua
    Lun, Zhao-Rong
    Holzmuller, Philippe
    Jittapalapong, Sathaporn
    [J]. BIOMED RESEARCH INTERNATIONAL, 2013, 2013
  • [9] A novel automated method to measure total antioxidant response against potent free radical reactions
    Erel, O
    [J]. CLINICAL BIOCHEMISTRY, 2004, 37 (02) : 112 - 119
  • [10] A new automated colorimetric method for measuring total oxidant status
    Erel, O
    [J]. CLINICAL BIOCHEMISTRY, 2005, 38 (12) : 1103 - 1111
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