Head injury and Parkinson's disease: A population-based study

被引：36

作者：

Fang, Fang ^{[1
]}

Chen, Honglei ^{[2
]}

Feldman, Adina L. ^{[1
]}

Kamel, Freya ^{[2
]}

Ye, Weimin ^{[1
]}

Wirdefeldt, Karin ^{[1
,3
]}

机构：

[1] Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden

[2] NIEHS, Epidemiol Branch, Res Triangle Pk, NC 27709 USA

[3] Karolinska Inst, Dept Clin Neurosci, SE-17177 Stockholm, Sweden

来源：

MOVEMENT DISORDERS | 2012年 / 27卷 / 13期

基金：

美国国家卫生研究院; 瑞典研究理事会;

关键词：

Parkinson disease; head injury; nested case-control study; odds ratio; ENVIRONMENTAL RISK-FACTORS; TRAUMATIC BRAIN-INJURY; HISTORY;

D O I：

10.1002/mds.25143

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: The epidemiological evidence on head injury and the risk of Parkinson's disease (PD) has been inconsistent. Methods: We examined the relation between previous hospitalization for head injury and PD using a population-based nested case-control design based on the Swedish National Patient Register from 2001 until 2007, including 18,648 PD cases and 93,240 controls, randomly selected from the general population. Exposure was defined as hospitalization for head injury between 1987 and index date. Results: Overall, previous hospitalization resulting from head injury was associated with an increased risk of PD; this association appeared to be largely explained by head injuries experienced recently, especially within 1 year before PD ascertainment. Conclusions: Our results do not provide convincing evidence for a causal relationship between head injury later in life and PD. (C) 2012 Movement Disorder Society

引用

页码：1632 / 1635

页数：4

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