Malnourished patients may experience a decrease in nutrient intake due to anorexia, nausea, and vomiting which can lead to further worsening the patient's condition. Insufficient nutritional intake causes undernutrition so it is necessary to administer a high calorie enteral formula to improve the nutritional status of the patient. The source of a grain-based protein based on dietary requirements is edamame. Edamame has a high protein content which reaches 36% higher than other types of soybeans. This study aims to analyze physical quality viscosity, determine the best treatment formulation, as well as the bioavailability of the best-treated protein with a standard hospital formula and analyze acceptability. Methods this study uses experimental laboratory. Added edamame flour treatment was 55%, 65%, 75%, 85%, and 95%. Conclusion the treatment of adding edamame flour as a modification material for high calorie formula gives a very real influence (Sig. < 0,01), the best treatment was obtained in the formula of high calorie modification of the third treatment edamame flour (P3) with the percentage addition of edamame flour 75%, and the formula for high calorie modification of edamame flour was not significantly different from the standard formula of the Hospital.