Bisorbibetanone, a novel oxidized sorbicillin dimer, with 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity from a fungus

被引：31

作者：

Abe, N ^{[1
]}

Murata, T ^{[1
]}

Yamamoto, K ^{[1
]}

Hirota, A ^{[1
]}

机构：

[1] Univ Shizuoka, Sch Food & Nutr Sci, Appl Microbiol Lab, Shizuoka 4228526, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 28期

关键词：

polyketide; fungi; stereochemistry; dimers;

D O I：

10.1016/S0040-4039(99)00938-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We isolated a novel oxidized sorbicillin dimer (1) as yellowish amorphous powder from the fermentation broth of Trichoderma sp. USF-2690 strain isolated from a soil sample. The structure of the compound was determined by elucidation of spectroscopic evidence. The compound was revealed to possess a new carbon skeleton in the group of oxidized sorbicillin dimers and was named bisorbibetanone. The stereostructure of bisorbibetanone was analyzed on the basis of the spectral data. In 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, bisorbibetanone gave an ED50 value of 62.5 mu M after standing for 30 min. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：5203 / 5206

页数：4