The advances in the regulation of immune microenvironment by Candida albicans and macrophage cross-talk

被引：6

作者：

Zhao, Shuo ^{[1
]}

Shang, Anquan ^{[2
]}

Guo, Mengchen ^{[1
]}

Shen, Liangliang ^{[1
]}

Han, Yu ^{[1
]}

Huang, Xin ^{[1
]}

机构：

[1] Tongji Univ, Tongji Hosp, Sch Med, Dept Dermatol, Shanghai, Peoples R China

[2] Second Peoples Hosp Lianyungang, Dept Lab Med, Lianyungang, Peoples R China

来源：

FRONTIERS IN MICROBIOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

Candida albicans; macrophages; PRR; PAMP; morphological transition; immune escape; GRAPHENE OXIDE NANOSHEETS; VIRULENCE; SURVIVAL;

D O I：

10.3389/fmicb.2022.1029966

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Candida albicans (C. albicans) is the most common causative agent of invasive fungal infections in hospitals. The body defends against and eliminates C. albicans infection by various mechanisms of immune response, and the latter mechanism of immune evasion is a major challenge in the clinical management of C. albicans infection. The role of macrophages in combating C. albicans infection has only recently been recognized, but the mechanisms remain to be elucidated. This review focuses on the interaction between C. albicans and macrophages (macrophages), which causes the body to generate an immune response or C. albicans immune escape, and then regulates the body's immune microenvironment, to explore the effect of C. albicans virulence resistance vs. macrophage killing and clarify the role and mechanism of C. albicans pathogenesis. In general, a thorough understanding of the molecular principles driving antifungal drug resistance is essential for the development of innovative treatments that can counteract both existing and emerging fungal threats.

引用

页数：8

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