In vitro human phase I metabolism of xenobiotics I: Pesticides and related chemicals used in agriculture and public health, September 2001

被引：30

作者：

Hodgson, E ^{[1
]}

机构：

[1] N Carolina State Univ, Dept Environm & Mol Toxicol, Raleigh, NC 27695 USA

来源：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2001年 / 15卷 / 06期

关键词：

human metabolism; cytochrome P-450; CYP; flavin-containing monooxygenase; FMO; pesticides;

D O I：

10.1002/jbt.10011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human phase I enzymes and their isoforms that metabolize pesticides are listed in a database that will be updated periodically. This initial version includes enzymes and isoforms that metabolize organophosphorus insecticides, chloroacetamide herbicides and triazine herbicides. (C) 2001 John Wiley & Sons, Inc.

引用

页码：296 / 299

页数：4

共 9 条

[1]

Butler AM, 1997, J PHARMACOL EXP THER, V280, P966

[2] In vitro metabolism of alachlor by human liver microsomes and human cytochrome P450 isoforms [J].

Coleman, S ;

Liu, SM ;

Linderman, R ;

Hodgson, E ;

Rose, RL .

CHEMICO-BIOLOGICAL INTERACTIONS, 1999, 122 (01) :27-39

[3] Comparative metabolism of chloroacetamide herbicides and selected metabolites in human and rat liver microsomes. [J].

Coleman, S ;

Linderman, R ;

Hodgson, E ;

Rose, RL .

ENVIRONMENTAL HEALTH PERSPECTIVES, 2000, 108 (12) :1151-1157

[4]

Hodgson E, 1998, PESTICIDES AND THE FUTURE, P231

[5]

Lang D, 1996, DRUG METAB DISPOS, V24, P859

[6] Identification of enzymes involved in the metabolism of atrazine, terbuthylazine, ametryne, and terbutryne in human liver microsomes [J].

Lang, DH ;

Rettie, AE ;

Bocker, RH .

CHEMICAL RESEARCH IN TOXICOLOGY, 1997, 10 (09) :1037-1044

[7] The role of metabolism in determining susceptibility to parathion toxicity in man [J].

Mutch, E ;

Blain, PG ;

Williams, FM .

TOXICOLOGY LETTERS, 1999, 107 (1-3) :177-187

[8] Evidence for the activation of organophosphate pesticides by cytochromes P450 3A4 and 2D6 in human liver microsomes [J].

Sams, C ;

Mason, HJ ;

Rawbone, R .

TOXICOLOGY LETTERS, 2000, 116 (03) :217-221

[9]

Tang J, 2001, DRUG METAB DISPOS, V29, P1201

← 1 →