Almond Skin Inhibits HSV-2 Replication in Peripheral Blood Mononuclear Cells by Modulating the Cytokine Network

被引：8

作者：

Arena, Adriana ^{[1
]}

Bisignano, Carlo ^{[2
]}

Stassi, Giovanna ^{[1
]}

Filocamo, Angela ^{[3
]}

Mandalari, Giuseppina ^{[3
]}

机构：

[1] Policlin Univ, Dept Human Pathol, I-98125 Messina, Italy

[2] Univ Messina, Dept Biol & Environm Sci, I-98100 Messina, Italy

[3] Vill SS Annunziata, Dept Drug Sci & Prod Hlth, I-98100 Messina, Italy

来源：

MOLECULES | 2015年 / 20卷 / 05期

关键词：

HSV-2; cytokines; IL-17; almond skins; VIRUS-INFECTION; EXPRESSION;

D O I：

10.3390/molecules20058816

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have investigated the effect of almond skin extracts on the production of pro-inflammatory and anti-inflammatory cytokines in human peripheral blood mononuclear cells (PBMCs). PBMCs were either infected or not by herpes simplex virus type 2 (HSV-2), with and without prior treatment with almond skin extracts. Production of IL-17 induced by HSV-2 was inhibited by natural skins (NS) treatment. NS triggered PBMC in releasing IFN-, IFN- and IL-4 in cellular supernatants. These results may explain the antiviral potential of almond skins.

引用

页码：8816 / 8822

页数：7

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