Effect of Age and Refractive Error on the Melanopsin Mediated Post-Illumination Pupil Response (PIPR)

被引：60

作者：

Adhikari, Prakash ^{[1
]}

Pearson, Candice A. ^{[1
]}

Anderson, Alexandra M. ^{[1
]}

Zele, Andrew J. ^{[1
]}

Feigl, Beatrix ^{[1
,2
]}

机构：

[1] Queensland Univ Technol, Inst Hlth & Biomed Innovat, Med Retina & Visual Sci Labs, Brisbane, Qld 4059, Australia

[2] Queensland Eye Inst, South Brisbane, Qld, Australia

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

基金：

澳大利亚研究理事会;

关键词：

RETINAL GANGLION-CELLS; FORM-DEPRIVATION MYOPIA; LIGHT REFLEX; DOPAMINE; SIZE; APOMORPHINE; PREVALENCE; INCREASES; FIELD;

D O I：

10.1038/srep17610

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Melanopsin containing intrinsically photosensitive Retinal Ganglion cells (ipRGCs) mediate the pupil light reflex (PLR) during light onset and at light offset (the post-illumination pupil response, PIPR). Recent evidence shows that the PLR and PIPR can provide non-invasive, objective markers of age-related retinal and optic nerve disease; however there is no consensus on the effects of healthy ageing or refractive error on the ipRGC mediated pupil function. Here we isolated melanopsin contributions to the pupil control pathway in 59 human participants with no ocular pathology across a range of ages and refractive errors. We show that there is no effect of age or refractive error on ipRGC inputs to the human pupil control pathway. The stability of the ipRGC mediated pupil response across the human lifespan provides a functional correlate of their robustness observed during ageing in rodent models.

引用

页数：10

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