Cerebrospinal fluid penetration and pharmacokinetic/pharmacodynamic parameters of intravenously administered colistin in a case of multidrug-resistant Acinetobacter baumannii meningitis

被引：123
|
作者：
Jiménez-Mejías, ME
Pichardo-Guerrero, C
Márquez-Rivas, FJ
Martín-Lozano, D
Prados, T
Pachón, J
机构：
[1] Univ Hosp Virgen Rocio, Infect Dis Serv, Seville 41013, Spain
[2] Univ Hosp Virgen Rocio, Neurosurg Serv, Seville 41013, Spain
[3] Univ Hosp Virgen Rocio, Microbiol Serv, Seville 41013, Spain
来源：
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2002年 / 21卷 / 03期
关键词：
D O I：
10.1007/s10096-001-0680-2
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Described here is a case of meningitis caused by multidrug-resistant Acinetobacter baumannii susceptible only to colistin, which was treated successfully with intravenous colistin sulfomethate sodium (5 mg/kg/day). The levels of colistin in serum and cerebrospinal fluid and the pharmacokinetic/pharmacodynamic parameters of colistin were determined. In this case, intravenously administered colistin penetrated cerebrospinal fluid (25% of serum levels) at levels sustaining bactericidal concentrations.
引用
收藏
页码：212 / 214
页数：3
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