N→S Acyl-Transfer-Mediated Synthesis of Peptide Thioesters Using Anilide Derivatives

被引：102
作者：
Tsuda, Shugo
Shigenaga, Akira
Bando, Kiyomi
Otaka, Akira [1 ]
机构：
[1] Univ Tokushima, Inst Hlth Biosci, Tokushima 7708505, Japan
来源：
ORGANIC LETTERS | 2009年 / 11卷 / 04期
关键词：
SOLID-PHASE SYNTHESIS; NATIVE CHEMICAL LIGATION; C-TERMINAL THIOESTERS; FMOC-BASED SYNTHESIS; SHIFT REACTION; SEMISYNTHESIS; GENERATION; PROTEINS; SCOPE;
D O I：
10.1021/ol8028093
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
N -> S acyl-transfer-mediated synthesis of peptide thioesters utilizing an N-aminoacyl-N-sulfanylethylaminobenzoic acid derivative has been examined. The developed synthetic methodology for peptide thioesters is compatible with Fmoc solid-phase peptide synthesis (SPPS).
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收藏
页码：823 / 826
页数：4
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