The nature of autoantigens targeted in autoimmune endocrine diseases

被引：51
作者：
Song, YH
Li, YX
Maclaren, NK
机构：
[1] Dept of Pathol. and Lab. Medicine, Univ. of Florida College of Medicine, Gainesville
来源：
IMMUNOLOGY TODAY | 1996年 / 17卷 / 05期
关键词：
D O I：
10.1016/0167-5699(96)10008-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Autoimmune endocrine diseases result from autoimmune processes involving autoreactive T cells and/or autoantibodies. Considerable progress has been made in elucidating the self- (auto-) antigens involved in these processes. membrane receptors, enzymes and secreted hormones. As discussed here by Yao-Hua Song and colleagues, diagnostic and therapeutic applications should now result from these discoveries.
引用
收藏
页码：232 / 238
页数：7
相关论文
共 82 条
[61]   CYTOTOXIC T-CELLS SPECIFIC FOR GLUTAMIC-ACID DECARBOXYLASE IN AUTOIMMUNE DIABETES [J].
PANINABORDIGNON, P ;
LANG, R ;
VANENDERT, PM ;
BENAZZI, E ;
FELIX, AM ;
PASTORE, RM ;
SPINAS, GA ;
SINIGAGLIA, F .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (05) :1923-1927
[62]   ISLET-CELL AUTOANTIGEN 69-KD (ICA69) - MOLECULAR-CLONING AND CHARACTERIZATION OF A NOVEL DIABETES-ASSOCIATED AUTOANTIGEN [J].
PIETROPAOLO, M ;
CASTANO, L ;
BABU, S ;
BUELOW, R ;
KUO, YLS ;
MARTIN, S ;
MARTIN, A ;
POWERS, AC ;
PROCHAZKA, M ;
NAGGERT, J ;
LEITER, EH ;
EISENBARTH, GS .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (01) :359-371
[63]  
POSILLICO JT, 1986, J BONE MINER RES, V1, P475
[64]   CLONING AND EXPRESSION OF IDDM-SPECIFIC HUMAN AUTOANTIGENS [J].
RABIN, DU ;
PLEASIC, SM ;
PALMERCROCKER, R ;
SHAPIRO, JA .
DIABETES, 1992, 41 (02) :183-186
[65]  
RABIN DU, 1994, J IMMUNOL, V152, P3183
[66]   A PROSPECTIVE-STUDY OF THE DEVELOPMENT OF DIABETES IN RELATIVES OF PATIENTS WITH INSULIN-DEPENDENT DIABETES [J].
RILEY, WJ ;
MACLAREN, NK ;
KRISCHER, J ;
SPILLAR, RP ;
SILVERSTEIN, JH ;
SCHATZ, DA ;
SCHWARTZ, S ;
MALONE, J ;
SHAH, S ;
VADHEIM, C ;
ROTTER, JI .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 323 (17) :1167-1172
[67]   HETEROGENEITY OF AUTOANTIBODIES AGAINST THYROID PEROXIDASE IN AUTOIMMUNE THYROID-DISEASE - EVIDENCE AGAINST ANTIBODIES DIRECTLY INHIBITING PEROXIDASE-ACTIVITY AS REGULATORY FACTORS IN THYROID-HORMONE METABOLISM [J].
SALLER, B ;
HORMANN, R ;
MANN, K .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1991, 72 (01) :188-195
[68]  
SANTAMARIA P, 1995, J IMMUNOL, V154, P2494
[69]   ISLET-CELL ANTIBODIES PREDICT INSULIN-DEPENDENT DIABETES IN UNITED-STATES SCHOOL-AGE-CHILDREN AS POWERFULLY AS IN UNAFFECTED RELATIVES [J].
SCHATZ, D ;
KRISCHER, J ;
HORNE, G ;
RILEY, W ;
SPILLAR, R ;
SILVERSTEIN, J ;
WINTER, W ;
MUIR, A ;
DEROVANESIAN, D ;
SHAH, S ;
MALONE, J ;
MACLAREN, N .
JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (06) :2403-2407
[70]  
SHIMIZU J, 1993, J IMMUNOL, V151, P1723
123456789