The nature of autoantigens targeted in autoimmune endocrine diseases

被引:51
作者
Song, YH
Li, YX
Maclaren, NK
机构
[1] Dept of Pathol. and Lab. Medicine, Univ. of Florida College of Medicine, Gainesville
来源
IMMUNOLOGY TODAY | 1996年 / 17卷 / 05期
关键词
D O I
10.1016/0167-5699(96)10008-6
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Autoimmune endocrine diseases result from autoimmune processes involving autoreactive T cells and/or autoantibodies. Considerable progress has been made in elucidating the self- (auto-) antigens involved in these processes. membrane receptors, enzymes and secreted hormones. As discussed here by Yao-Hua Song and colleagues, diagnostic and therapeutic applications should now result from these discoveries.
引用
收藏
页码:232 / 238
页数:7
相关论文
共 82 条
[1]   AN AUTOIMMUNE-DISEASE WITH MULTIPLE MOLECULAR TARGETS ABROGATED BY THE TRANSGENIC EXPRESSION OF A SINGLE AUTOANTIGEN IN THE THYMUS [J].
ALDERUCCIO, F ;
TOH, BH ;
TAN, SS ;
GLEESON, PA ;
VANDRIEL, IR .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) :419-426
[2]   Imogen 38: A novel 38-kD islet mitochondrial autoantigen recognized by T cells from a newly diagnosed type 1 diabetic patient [J].
Arden, SD ;
Roep, BO ;
Neophytou, PI ;
Usac, EF ;
Duinkerken, G ;
deVries, RRP ;
Hutton, JC .
JOURNAL OF CLINICAL INVESTIGATION, 1996, 97 (02) :551-561
[3]   ISLET-CELL AUTOANTIGENS IN INSULIN-DEPENDENT DIABETES [J].
ATKINSON, MA ;
MACLAREN, NK .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (04) :1608-1616
[4]   AUTOANTIBODIES IN NONOBESE DIABETIC MICE IMMUNOPRECIPITATE 64,000-MR ISLET ANTIGEN [J].
ATKINSON, MA ;
MACLAREN, NK .
DIABETES, 1988, 37 (11) :1587-1590
[5]   INSULITIS AND DIABETES IN NOD MICE REDUCED BY PROPHYLACTIC INSULIN THERAPY [J].
ATKINSON, MA ;
MACLAREN, NK ;
LUCHETTA, R .
DIABETES, 1990, 39 (08) :933-937
[6]   AUTOANTIBODIES IN NEWLY DIAGNOSED DIABETIC CHILDREN IMMUNOPRECIPITATE HUMAN PANCREATIC-ISLET CELL-PROTEINS [J].
BAEKKESKOV, S ;
NIELSEN, JH ;
MARNER, B ;
BILDE, T ;
LUDVIGSSON, J ;
LERNMARK, A .
NATURE, 1982, 298 (5870) :167-169
[7]   ANTIBODIES TO A 64,000 MR HUMAN ISLET CELL ANTIGEN PRECEDE THE CLINICAL ONSET OF INSULIN-DEPENDENT DIABETES [J].
BAEKKESKOV, S ;
LANDIN, M ;
KRISTENSEN, JK ;
SRIKANTA, S ;
BRUINING, GJ ;
MANDRUPPOULSEN, T ;
DEBEAUFORT, C ;
SOELDNER, JS ;
EISENBARTH, G ;
LINDGREN, F ;
SUNDQUIST, G ;
LERNMARK, A .
JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (03) :926-934
[8]   IDENTIFICATION OF THE 64K AUTOANTIGEN IN INSULIN-DEPENDENT DIABETES AS THE GABA-SYNTHESIZING ENZYME GLUTAMIC-ACID DECARBOXYLASE [J].
BAEKKESKOV, S ;
AANSTOOT, HJ ;
CHRISTGAU, S ;
REETZ, A ;
SOLIMENA, M ;
CASCALHO, M ;
FOLLI, F ;
RICHTEROLESEN, H ;
CAMILLI, PD .
NATURE, 1990, 347 (6289) :151-156
[9]  
Blizzard R M, 1966, Clin Exp Immunol, V1, P119
[10]   PERIPHERIN - AN ISLET ANTIGEN THAT IS CROSS-REACTIVE WITH NONOBESE DIABETIC MOUSE CLASS-II GENE-PRODUCTS [J].
BOITARD, C ;
VILLA, MC ;
BECOURT, C ;
GIA, HP ;
HUC, C ;
SEMPE, P ;
PORTIER, MM ;
BACH, JF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (01) :172-176