Synthesis and Anticancer Activity of Lanthanum(III) Complexes with 1,10-phenanthroline Bridged by Diamines

Three Lathanum (III) complexes with 1,10-phenanthroline bridged by ethylenediamine, 1,3-propylenediamine and 1,2-propylenediamine were synthesized and characterized. All Complexes have been assayed for antitumor activity in vitro against human leukocytoma HL-60 cells, human prostate carcinoma PC-3MIE8 cells, human stomach carcinoma BGC-823 cells, human galactophore carcinoma MDA-MB-435 cells, human liver carcinoma Bel-7402 cells, human cervix carcinoma Hela cells. The results show that the three complexes exhibit good growth inhibition against different cell lines in general. DNA binding studies indicate that the complexes possibly interact with ctDNA by part intercalative, covalent binding and electrostatic effection.