In vivo quantitative photoacoustic evaluation of the liver and kidney pathology in tyrosinemia

被引：43

作者：

Huang, Guojia ^{[1
]}

Lv, Jing ^{[1
,2
,3
]}

He, Yong ^{[4
]}

Yang, Jian ^{[5
]}

Zeng, Lvming ^{[4
]}

Nie, Liming ^{[1
,6
]}

机构：

[1] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Res Ctr Med Sci, Guangzhou 510000, Peoples R China

[2] Guangdong Cardiovsac Inst, Guangzhou 510000, Peoples R China

[3] Xiamen Univ, Sch Publ Hlth, Xiamen 361005, Peoples R China

[4] Guangdong Univ Technol, State Key Lab Precis Elect Mfg Technol & Equipment, Guangzhou 510000, Peoples R China

[5] Southern Med Univ, Zhujiang Hosp, Dept Hepatobiliary Surg, Guangzhou 510000, Peoples R China

[6] Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Guangdong Prov Key Lab Artificial Intelligence Med, Guangzhou 510000, Peoples R China

来源：

PHOTOACOUSTICS | 2022年 / 28卷

基金：

中国国家自然科学基金;

关键词：

Photoacoustic imaging; Tyrosinemia; Hepatic lobule; Renal tubule; CLINICAL FORMS; TYPE-1; FUMARYLACETOACETATE; TOMOGRAPHY; INJURY; VISUALIZATION; NITISINONE; DIAGNOSIS; CHILDREN; SURGERY;

D O I：

10.1016/j.pacs.2022.100410

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

Hereditary tyrosinemia type I (HT1) is a severe autosomal recessive inherited metabolic disease, which can result in severe damage of liver and kidney. Photoacoustic imaging (PAI) uses pulsed laser light to induce ultrasonic signals to facilitate the visualization of lesions that are strongly related to disease progression. In this study, the structural and functional changes of liver and kidney in HT1 was investigated by cross-scale PAI. The results showed that the hepatic lobule and renal tubule were severely damaged during HT1 progression. The hemoglobin content, vessel density, and liver function reserve were decreased. The metabolic half-life of indocyanine green declined from 59.8 s in health to 262.6 s in the advanced stage. Blood oxygen saturation was much lower than that in health. This study highlights the potential of PAI for in vivo evaluation of the liver and kidney lesions in HT1.

引用

页数：10

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