Extent and consequences of inadequate disease control among adults with a history of moderate to severe atopic dermatitis

被引:62
作者
Wei, Wenhui [1 ]
Anderson, Peter [2 ]
Gadkari, Abhijit [3 ]
Blackburn, Stuart [2 ]
Moon, Rachel [2 ]
Piercy, James [2 ]
Shinde, Shashank [1 ]
Gomez, Jorge [3 ]
Ghorayeb, Eric [1 ]
机构
[1] Sanofi, Bridgewater, MA USA
[2] Adelphi Real World, Bollington, Cheshire, England
[3] Regeneron Pharmaceut Inc, New York, NY USA
关键词
atopic dermatitis; burden; disease control; patient-reported outcomes; quality of life; QUALITY-OF-LIFE; ECZEMA AREA; ACTIVITY IMPAIRMENT; WORK PRODUCTIVITY; JAPANESE PATIENTS; INDEX EASI; BURDEN; GUIDELINES; MANAGEMENT; IMPACT;
D O I
10.1111/1346-8138.14116
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Since control of atopic dermatitis (AD) remains challenging but has not been adequately characterized, the objective of this study was to characterize disease control among patients with a history of moderate to severe AD. Data were from the 2014 Adelphi US AD Disease Specific Programme, a cross-sectional survey of physicians (n=202) and their patients with history of moderate to severe AD (n=1064, 54% female, 75% white, mean age 40years). Inadequately controlled AD as rated by the physician was defined as currently flaring; deteriorating/changeable AD; or physician dissatisfaction with current control. The overall inadequate control rate was 58.7% (n=625), which increased with current AD severity and was observed in 53.4% and 83.4% of patients receiving immunosuppressants and systemic corticosteroids, respectively. Relative to controls, inadequately controlled patients had poorer disease-specific quality of life, higher level of work impairment, greater itch and sleep interference with daily living (all P<0.05). Multivariate analysis showed factors significantly associated with inadequate control (all P<0.05), including Hispanic race, symptoms on the head/neck or lower limbs, itch and sleep interference with daily living. A limitation of the study was reliance on accuracy of reporting, potential selection bias and cross-sectional study design. In summary, there was a high rate and substantial impact of physician-rated inadequately controlled disease among patients with a history of moderate to severe AD, suggesting the need for more effective therapies.
引用
收藏
页码:150 / 157
页数:8
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