Alternative splicing of mutually exclusive exons-A review

被引：57

作者：

Pohl, Martin ^{[1
]}

Bortfeldt, Ralf H. ^{[2
]}

Gruetzmann, Konrad ^{[1
]}

Schuster, Stefan ^{[1
]}

机构：

[1] Univ Jena, Dept Bioinformat, D-07743 Jena, Germany

[2] Humboldt Univ, Dept Crop & Anim Sci, D-10115 Berlin, Germany

来源：

BIOSYSTEMS | 2013年 / 114卷 / 01期

关键词：

Alternative splicing; Exon clusters; Mutually exclusive exons; Non-sense mediated decay; Splicing mechanisms; RNA SECONDARY STRUCTURE; MESSENGER-RNA; TRANSCRIPTIONAL INITIATION; DROSOPHILA-DSCAM; DATABASE; EVENTS; BIOINFORMATICS; MECHANISMS; DIVERSITY; SITE;

D O I：

10.1016/j.biosystems.2013.07.003

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Alternative splicing (AS) of pre-mRNAs in higher eukaryotes and several viruses is one major source of protein diversity. Usually, the following major subtypes of AS are distinguished: exon skipping, intron retention, and alternative 3' and 5' splice sites. Moreover, mutually exclusive exons (MXEs) represent a rare subtype. In the splicing of MXEs, two (or more) splicing events are not independent anymore, but are executed or disabled in a coordinated manner. In this review, several bioinformatics approaches for analyzing MXEs are presented and discussed. In particular, we revisit suitable definitions and nomenclatures, and bioinformatics tools for finding MXEs, adjacent and non-adjacent MXEs, clustered and grouped MXEs. Moreover, the molecular mechanisms for splicing MXEs proposed in the literature are reviewed and discussed. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：31 / 38

页数：8

共 117 条

[91] How prevalent is functional alternative splicing in the human genome? [J].