Solubility of mesalazine in polyethylene glycol 400+water mixtures at different temperatures

被引：15

作者：

Moradi, Milad ^{[1
,2
,3
]}

Rahimpour, Elaheh ^{[2
,3
,4
]}

Hemmati, Salar ^{[5
]}

Martinez, Fleming ^{[6
]}

Barzegar-Jalali, Mohammad ^{[3
,7
]}

Jouyban, Abolghasem ^{[2
,3
,8
]}

机构：

[1] Tabriz Univ Med Sci, Fac Pharm, Student Res Comm, Tabriz, Iran

[2] Tabriz Univ Med Sci, Pharmaceut Anal Res Ctr, Tabriz, Iran

[3] Tabriz Univ Med Sci, Fac Pharm, Tabriz, Iran

[4] Tabriz Univ Med Sci, Food & Drug Safety Res Ctr, Tabriz, Iran

[5] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[6] Univ Nacl Colombia, Fac Ciencias, Dept Farm, Grp Invest Farmaceut Fisicoquim,Sede Bogota, Cra 30 45-03, Bogota, DC, Colombia

[7] Tabriz Univ Med Sci, Res Ctr Pharmaceut Nanotechnol, Tabriz, Iran

[8] Univ Tehran Med Sci, Digest Dis Res Inst, Tehran, Iran

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2020年 / 314卷

关键词：

Solubility; Mesalazine; Polyethylene glycol 400; Cosolvency models; Dissolution thermodynamics; Preferential solvation; PREFERENTIAL SOLVATION; COSOLVENCY; PREDICTION; MODELS; DRUGS;

D O I：

10.1016/j.molliq.2020.113546

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Temperature-dependent solubility data for mesalazine in the binary system of polyethylene glycol 400 (PEG 400)/water are determined by a shake-flask method at 293.2-313.2 K. The solubility data are validated to five different computational models including the van't Hoff, the mixture response surface, the Yalkowsky, the Jouyban-Acree, and the Jouyban-Acree-van't Hoff. All the investigated models have good correlation and validation according to obtained the mean relative deviations (MRD%) for back-calculated data. Moreover, apparent thermodynamic analysis shows an endothemiic process for mesalazine in (PEG 400 +/- water) mixtures. Further, based on inverse Kirkwood-Buff integrals is observed that mesalazine is preferentially solvated by PEG in all the mixtures. (C) 2020 Elsevier B.V. All rights reserved.

引用

页数：8