Chitosan films modified selectively on one side with dendritic molecules

Novel chitosan films dendronized on one side were prepared by reaction between a cross-linked biopolymer and weisocyanate dendron. According to ATR-FTIR analysis, it can be concluded that the dendronization took place on only one of the faces of the films. The highlight of this work is that the modification grants different hydrophilic and hydrophobic properties on both sides of the system. Interactions between the dendron-polymer network and the hydrophobic characteristics of the dendron modify the physical properties of the films. As the thermal stability of the films increases, the degree of swelling and WVP values decrease, and the elastic modulus increases, turning the network more rigid. The dendronized films were swollen at pH 3.4 and 6.8 which are the pHs of the different wound healing stages. The films remained stable for an extended period. The films obtained can be potentially applied as wound dressings able to maintain a moist environment at the wound interface and act as a barrier to microorganisms, removing excess exudates. The product is made from a readily available biomaterial that requires minimal processing, possesses antimicrobial properties and could promote wound healing.