Biosynthesis, Natural Sources, Dietary Intake, Pharmacokinetic Properties, and Biological Activities of Hydroxycinnamic Acids

被引：355
作者：
El-Seedi, Hesham R. [1 ,2 ]
El-Said, Asmaa M. A. [2 ]
Khalifa, Shaden A. M. [3 ]
Goransson, Ulf [1 ]
Bohlin, Lars [1 ]
Borg-Karlson, Anna-Karin [4 ]
Verpoorte, Rob [5 ]
机构：
[1] Uppsala Univ, Dept Med Chem, Biomed Ctr, Div Pharmacognosy, SE-75123 Uppsala, Sweden
[2] Menoufia Univ, Dept Chem, Fac Sci, Shibin Al Kawm 32512, Egypt
[3] KI, Dept Clin Neurosci, Stockholm, Sweden
[4] Sch Chem Sci & Technol, Dept Chem, Ecologial Chem Grp, Stockholm, Sweden
[5] Leiden Univ, Inst Biol, Metab Sect, NL-2300 RA Leiden, Netherlands
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2012年 / 60卷 / 44期
基金：
瑞典研究理事会;
关键词：
absorption; antioxidant; biosynthesis; dietary intake; hydroxycinnamic acids; phenolic acids; metabolism; natural sources; LOW-DENSITY-LIPOPROTEIN; BOUND PHENOLIC-ACIDS; POTENTIAL ANTICANCER ACTIVITY; CATECHOL-O-METHYLTRANSFERASE; RADICAL SCAVENGING ACTIVITY; CISPLATIN-INDUCED DELAY; CORONARY-HEART-DISEASE; P-COUMARIC ACIDS; CAFFEIC ACID; FERULIC ACID;
D O I：
10.1021/jf301807g
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
Hydroxycinnamic acids are the most widely distributed phenolic acids in plants. Broadly speaking, they can be defined as compounds derived from cinnamic acid. They are present at high concentrations in many food products, including fruits, vegetables, tea, cocoa, and wine. A diet rich in hydroxycinnamic acids is thought to be associated with beneficial health effects such as a reduced risk of cardiovascular disease. The impact of hydroxycinnamic acids on health depends on their intake and pharmacokinetic properties. This review discusses their chemistry, biosynthesis, natural sources, dietary intake, and pharmacokinetic properties.
引用
收藏
页码：10877 / 10895
页数：19
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