A partial BRCA1 sequence homology mapping to 4q28

被引：2

作者：

Stec, I

van Vliet, M

van Eijk, R

Meijers, H

Kroeze, KHG

Dauwerse, JG

van Ommen, GJB

Cornelisse, CJ

den Dunnen, JT

Devilee, P

机构：

[1] Leiden Univ, Med Ctr, Dept Human & Clin Genet, NL-2333 AL Leiden, Netherlands

[2] Dept Human & Clin Genet, Rotterdam, Netherlands

来源：

CYTOGENETICS AND CELL GENETICS | 2001年 / 94卷 / 1-2期

关键词：

D O I：

10.1159/000048777

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Using a BRCA1 cDNA probe in Southern analysis, we detected a sequence of 348 by on 4q28 that is homologous to the 3' end of BRCA1. A 28-kb sequence contig has been assembled spanning the homologous region, which we designated BRCA1-h. An open reading frame was identified encoding a sequence of 82 amino acids; 22 of the last 23 amino acids are identical to the last 23 residues of BRCA1. BLAST-searches. RT-PCR and RACE-experiments have been unable to provide evidence that BRCA1-h is part of an expressed gene. Copyright (C) 2001 S. Karger AG, Basel.

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页码：26 / 29

页数：4

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