Structure and function of streptococcal and staphylococcal superantigens in septic shock

被引:37
作者
Bannan, J
Visvanathan, K
Zabriskie, JB
机构
[1] Rockefeller Univ, Lab Clin Microbiol & Immunol, New York, NY 10021 USA
[2] Vanderbilt Univ, Dept Pathol, Nashville, TN USA
关键词
D O I
10.1016/S0891-5520(05)70081-7
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The pyrogenic exotoxins of Group A Streptococci and enterotoxins of Staphylococcus aureus constitute a family of related toxins that acts as "superantigens" because of their ability to stimulate large numbers of T-cell subsets. These toxins have been implicated in gastrointestinal food poisoning, toxic shock syndromes, Gram-positive sepsis, and, possibly, septic shock. There is increasing evidence that Gram-positive infections frequently coexist in septic shock and that bacterial superantigens play a major role.
引用
收藏
页码:387 / +
页数:11
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