Ni-Catalyzed Stereoselective Arylation of Inert C-O bonds at Low Temperatures

被引：82

作者：

Cornella, Josep ^{[1
]}

Martin, Ruben ^{[1
,2
]}

机构：

[1] Inst Chem Res Catalonia ICIQ, Tarragona 43007, Spain

[2] Catalan Inst Res & Adv Studies ICREA, Barcelona 08010, Spain

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 24期

基金：

欧洲研究理事会;

关键词：

CROSS-COUPLING REACTIONS; ARYL GRIGNARD-REAGENTS; CARBON-CARBON BONDS; HETEROCYCLIC CARBENES; ORGANOBORON COMPOUNDS; OXIDATIVE ADDITION; NICKEL; ETHERS; COMPLEXES; PALLADIUM;

D O I：

10.1021/ol4031815

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Ni-catalyzed arylation of inert C-O bonds that operates at temperatures as low as -40 degrees C is described. Unlike other methods for C-O bond cleavage utilizing organometallic species, this protocol operates at low temperatures, thus allowing the presence of sensitive functional groups with exquisite site-selectivity and stereoselectivity.

引用

页码：6298 / 6301

页数：4

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