Pathological Potential of Astroglia

被引：24

作者：

Chvatal, A. ^{[1
,2
]}

Anderova, M. ^{[1
,2
]}

Neprasova, H. ^{[1
,2
]}

Prajerova, I. ^{[1
,2
]}

Benesova, J. ^{[1
,2
]}

Butenko, O. ^{[1
]}

Verkhratsky, A. ^{[1
,3
]}

机构：

[1] Acad Sci Czech Republ, Inst Expt Med, Videnska 1083, Prague 14220 4, Czech Republic

[2] Charles Univ Prague, Ctr Cell Therapy & Tissue Repair, Prague, Czech Republic

[3] Univ Manchester, Fac Life Sci, Manchester, Lancs, England

来源：

PHYSIOLOGICAL RESEARCH | 2008年 / 57卷

基金：

英国惠康基金;

关键词：

Astrocyte; Astrogliosis; Brain pathology; Brain damage and repair; Ischemia; Acute brain trauma; Neurodegeneration;

D O I：

10.33549/physiolres.931604

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The pathological potential of glial cells was recognized already by Rudolf Virchow, Santiago Ramon y Cajal and Pio Del Rio-Ortega. Many functions and roles performed by astroglia in the healthy brain determine their involvement in brain diseases; as indeed any kind of brain insult does affect astrocytes, and their performance in pathological conditions, to a very large extent, determines the survival of the brain parenchyma, the degree of damage and neurological defect. Astrocytes being in general responsible for overall brain homeostasis are involved in virtually every form of brain pathology. Here we provide an overview of recent developments in identifying the role and mechanisms of the pathological potential of astroglia.

引用

页码：S101 / S110

页数：10

共 92 条

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