A review of the toxicology and pathology of the gastrointestinal tract

被引：12
作者：
Betton, G. R. [1 ]
机构：
[1] Betton ToxPath Consulting LLP, Macclesfield SK11 0SE, Cheshire, England
来源：
CELL BIOLOGY AND TOXICOLOGY | 2013年 / 29卷 / 05期
关键词：
Gastrointestinal toxicity; Xenobiotics; Intestinal metabolism; Neuroendocrine; Carcinogenesis; ENTERIC NERVOUS-SYSTEM; EPSTEIN-BARR-VIRUS; MUCOUS NECK CELL; HELICOBACTER-PYLORI; GASTRIC-MUCOSA; FORESTOMACH TUMORS; EPITHELIAL-CELLS; OXYNTIC ATROPHY; ANIMAL-MODELS; RAT;
D O I：
10.1007/s10565-013-9257-y
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The gastrointestinal tract of man and animals shows great specialization in structure and function for its primary role of digestion. There are many species differences in diet, anatomy and metabolism, and its neuroendocrine regulation has evolved into a complex field for investigation. Exposure of the tract from oral cavity, stomach, small and large intestine results in a range of toxicities covered by this review. Carcinogenesis of the gastrointestinal tract by a range of agents including pharmaceuticals is also discussed.
引用
收藏
页码：321 / 338
页数：18
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