Siegesbeckia pubescens ameliorates experimental ulcerative colitis in rats by modulating PPARγ

被引：0
|
作者：
Teng, Tianli [1 ,3 ]
Xu, Shifang [1 ]
Chen, Qun [2 ]
Chen, Fengyang [1 ]
Li, Xiaoyu [1 ]
Gao, Lijuan [1 ]
Hao, Shujuan [1 ]
Ye, Yiping [1 ]
机构：
[1] Zhejiang Acad Med Sci, Inst Materia Med, Tianmushan Rd 182, Hangzhou 310013, Zhejiang, Peoples R China
[2] Ningbo Coll Hlth Sci, Ningbo 315100, Zhejiang, Peoples R China
[3] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Pharm, Hangzhou 310003, Zhejiang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 12期
基金：
美国国家科学基金会;
关键词：
Siegesbeckia pubescens; ulcerative colitis; TNBS; PPAR gamma; ACTIVATED RECEPTOR-GAMMA; NF-KAPPA-B; INDUCED MODEL; ENT-KAURANE; INFLAMMATION; DITERPENOIDS; HETERODIMER; MACROPHAGES; MECHANISMS; EXPRESSION;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Siegesbeckia pubescens is a traditional Chinese medicine widely used for the treatment of inflammatory and autoimmune diseases in clinic. In order to evaluate its therapeutic effect against ulcerative colitis (UC) and elucidate its possible mechanisms, in this study, the effect of aqueous extract of S. pubescens (SPA) on 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced experimental UC in rats was determined. The results showed that oral administration of SPA significantly ameliorated colonic edema, hyperemia, inflammation and anabrosis in TNBS-induced experimental UC in rats. In addition, SPA inhibited MPO and pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6 and IFN-gamma) production, and up-regulated PPAR. expression in colon. These results indicated that SPA has therapeutic effects against TNBS-induced experimental UC in rats, and its underlying mechanisms involve the modulation of PPAR gamma-mediated production of inflammatory mediators. These findings highlight the potential of this traditional Chinese medicine as an agent for use in the treatment of UC.
引用
收藏
页码：23082 / 23091
页数：10
相关论文
共 50 条
  • [31] Rheinic acid ameliorates radiation-induced acute enteritis in rats through PPAR-γ/NF-κB
    Sha, Haixia
    Gu, Yu
    Shen, Weixing
    Zhang, Li
    Qian, Fei
    Zhao, Yudong
    Li, Haixiao
    Zhang, Ting
    Lu, Weimin
    GENES & GENOMICS, 2019, 41 (08) : 909 - 917
  • [32] Modulating effect of Biophytum sensitivum extract on rats with acetic acid-induced ulcerative colitis
    Sakthivel, K. M.
    Guruvayoorappan, C.
    PHARMACEUTICAL BIOLOGY, 2014, 52 (12) : 1570 - 1580
  • [33] Intestinal steroidogenesis controls PPAR expression in the colon and is impaired during ulcerative colitis
    Bouguen, Guillaume
    Langlois, Audrey
    Djouina, Madjid
    Branche, Julien
    Koriche, Dine
    Dewaeles, Edmone
    Mongy, Alice
    Auwerx, Johan
    Colombel, Jean-Frederic
    Desreumaux, Pierre
    Dubuquoy, Laurent
    Bertin, Benjamin
    GUT, 2015, 64 (06) : 901 - 910
  • [34] Geraniol ameliorates TNBS-induced colitis: Involvement of Wnt/β-catenin, p38MAPK, NFκB, and PPARγ signaling pathways
    Soubh, Ayman A.
    Abdallah, Dalaal M.
    El-Abhar, Hanan S.
    LIFE SCIENCES, 2015, 136 : 142 - 150
  • [35] Olmesartan ameliorates chemically-induced ulcerative colitis in rats via modulating NFκB and Nrf-2/HO-1 signaling crosstalk
    Saber, Sameh
    Khalil, Rania M.
    Abdo, Walied S.
    Nassif, Doaa
    El-Ahwany, Eman
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2019, 364 : 120 - 132
  • [36] Dihydrotanshinone I, a natural product, ameliorates DSS-induced experimental ulcerative colitis in mice
    Guo, Yanling
    Wu, Xiaxia
    Wu, Qin
    Lu, Yuanfu
    Shi, Jingshan
    Chen, Xiuping
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2018, 344 : 35 - 45
  • [37] Fecal microbiota transplantation ameliorates active ulcerative colitis
    Chen, Hui-Ting
    Huang, Hong-Li
    Xu, Hao-Ming
    Luo, Qing-Ling
    He, Jie
    Li, Yong-Qiang
    Zhou, You-Lian
    Nie, Yu-Qiang
    Zhou, Yong-Jian
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2020, 19 (04) : 2650 - 2660
  • [38] Phloretin ameliorates dextran sulfate sodium-induced ulcerative colitis in mice by regulating the gut microbiota
    Wu, Minna
    Li, Puze
    An, Yunying
    Ren, Jie
    Yan, Dong
    Cui, Jiazeng
    Li, Duan
    Li, Min
    Wang, Mingyong
    Zhong, Genshen
    PHARMACOLOGICAL RESEARCH, 2019, 150
  • [39] Gancao Xiexin Decoction Ameliorates Ulcerative Colitis in Mice via Modulating Gut Microbiota and Metabolites
    Luo, Yi-Ting
    Wu, Jin
    Zhu, Fang-Yuan
    Wu, Jia-Qian
    Wu, Pei
    Liu, Ying-Chao
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2022, 16 : 1383 - 1405
  • [40] Lizhong decoction ameliorates ulcerative colitis in mice via modulating gut microbiota and its metabolites
    Junfeng Zou
    Yumeng Shen
    Mengjun Chen
    Zhimiao Zhang
    Suwei Xiao
    Chen Liu
    Yue Wan
    Lei Yang
    Shu Jiang
    Erxin Shang
    Dawei Qian
    Jinao Duan
    Applied Microbiology and Biotechnology, 2020, 104 : 5999 - 6012
12345