Siegesbeckia pubescens ameliorates experimental ulcerative colitis in rats by modulating PPARγ

被引：0
|
作者：
Teng, Tianli [1 ,3 ]
Xu, Shifang [1 ]
Chen, Qun [2 ]
Chen, Fengyang [1 ]
Li, Xiaoyu [1 ]
Gao, Lijuan [1 ]
Hao, Shujuan [1 ]
Ye, Yiping [1 ]
机构：
[1] Zhejiang Acad Med Sci, Inst Materia Med, Tianmushan Rd 182, Hangzhou 310013, Zhejiang, Peoples R China
[2] Ningbo Coll Hlth Sci, Ningbo 315100, Zhejiang, Peoples R China
[3] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Pharm, Hangzhou 310003, Zhejiang, Peoples R China
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 12期
基金：
美国国家科学基金会;
关键词：
Siegesbeckia pubescens; ulcerative colitis; TNBS; PPAR gamma; ACTIVATED RECEPTOR-GAMMA; NF-KAPPA-B; INDUCED MODEL; ENT-KAURANE; INFLAMMATION; DITERPENOIDS; HETERODIMER; MACROPHAGES; MECHANISMS; EXPRESSION;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Siegesbeckia pubescens is a traditional Chinese medicine widely used for the treatment of inflammatory and autoimmune diseases in clinic. In order to evaluate its therapeutic effect against ulcerative colitis (UC) and elucidate its possible mechanisms, in this study, the effect of aqueous extract of S. pubescens (SPA) on 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced experimental UC in rats was determined. The results showed that oral administration of SPA significantly ameliorated colonic edema, hyperemia, inflammation and anabrosis in TNBS-induced experimental UC in rats. In addition, SPA inhibited MPO and pro-inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6 and IFN-gamma) production, and up-regulated PPAR. expression in colon. These results indicated that SPA has therapeutic effects against TNBS-induced experimental UC in rats, and its underlying mechanisms involve the modulation of PPAR gamma-mediated production of inflammatory mediators. These findings highlight the potential of this traditional Chinese medicine as an agent for use in the treatment of UC.
引用
收藏
页码：23082 / 23091
页数：10
相关论文
共 50 条
  • [1] Siegesbeckia pubescens Attenuates Iodoacetamide-induced Colitis in Rats
    Chen, Feng-yang
    Teng, Tian-li
    Li, Qin
    Xu, Shi-fang
    Chen, Qun
    Li, Xiao-yu
    Ye, Yi-ping
    INTERNATIONAL JOURNAL OF PHARMACOLOGY, 2016, 12 (07) : 711 - 719
  • [2] Paeonol Ameliorates Ulcerative Colitis in Mice by Modulating the Gut Microbiota and Metabolites
    Zheng, Jiahui
    Li, Huan
    Zhang, Pei
    Yue, Shijun
    Zhai, Bingtao
    Zou, Junbo
    Cheng, Jiangxue
    Zhao, Chongbo
    Guo, Dongyan
    Wang, Jing
    METABOLITES, 2022, 12 (10)
  • [3] Inula viscosa ameliorates acetic acid induced ulcerative colitis in rats
    Cellat, Mustafa
    Tekeli, Ibrahim Ozan
    Turk, Erdinc
    Aydin, Tuba
    Uyar, Ahmet
    Isler, Cafer Tayer
    Gokcek, Ishak
    Etyemez, Muhammed
    Guvenc, Mehmet
    BIOTECHNIC & HISTOCHEMISTRY, 2023, 98 (04) : 255 - 266
  • [4] Modulating Effect of Paeonol on Piglets With Ulcerative Colitis
    Wang, Shanshan
    Bai, Miaomiao
    Shu, Qingyan
    Liu, Zhengan
    Shao, Yirui
    Xu, Kang
    Xiong, Xia
    Liu, Hongnan
    Li, Yao
    FRONTIERS IN NUTRITION, 2022, 9
  • [5] Protective effects of pterostilbene on ulcerative colitis in rats via suppressing NF-κB pathway and activating PPAR-γ
    Shi, Liu
    Liu, Qing
    Tang, Jian-hua
    Wen, Jian-jun
    Li, Chen
    EUROPEAN JOURNAL OF INFLAMMATION, 2019, 17
  • [6] Keratinocyte growth factor gene therapy ameliorates ulcerative colitis in rats
    Liu, Chun-Jie
    Jin, Ji-De
    Lv, Tong-De
    Wu, Zu-Ze
    Ha, Xiao-Qin
    WORLD JOURNAL OF GASTROENTEROLOGY, 2011, 17 (21) : 2632 - 2640
  • [7] PPARγ: The Central Mucus Barrier Coordinator in Ulcerative Colitis
    Fang, Jian
    Wang, Hui
    Xue, Zhe
    Cheng, Yinyin
    Zhang, Xiaohong
    INFLAMMATORY BOWEL DISEASES, 2021, 27 (05) : 732 - 741
  • [8] Modulating effect of ginger extract on rats with ulcerative colitis
    El-Abhar, Hanan S.
    Hammad, Lamiaa N. A.
    Gawad, Hala S. Abdel
    JOURNAL OF ETHNOPHARMACOLOGY, 2008, 118 (03) : 367 - 372
  • [9] Paeonol alleviates ulcerative colitis by modulating PPAR-γ and nuclear factor-κB activation
    Cheng, Shuyu
    Chen, Wujin
    Guo, Zhenzhen
    Ding, Chenchun
    Zuo, Renjie
    Liao, Quan
    Liu, Guoyan
    SCIENTIFIC REPORTS, 2024, 14 (01):
  • [10] Yarrow oil ameliorates ulcerative colitis in mice model via regulating the NF-κB and PPAR-γ pathways
    Mohamed, Maged E.
    Elsayed, Sahar A.
    Madkor, Hafez R.
    Eldien, Heba M. Saad
    Mohafez, Omar M.
    INTESTINAL RESEARCH, 2021, 19 (02) : 194 - 205
12345