Synthesis of spiro[pyrazolo[3,4-b] pyridine-4,3′-indoline] and spiro [benzo[h]pyrazolo[3,4-b]quinoline-4,3′-indoline] derivatives using wet cyanuric chloride under solvent-free conditions

被引：12

作者：

Yin, Zhikui ^{[1
]}

Yang, Limin ^{[1
]}

Wu, Liqiang ^{[1
]}

机构：

[1] Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China

来源：

JOURNAL OF CHEMICAL SCIENCES | 2013年 / 125卷 / 03期

关键词：

Cyanuric chloride; spiro[benzo[h]pyrazolo[3,4-b]quinoline-4,3 '-indoline; spiro[pyrazolo[3,4-b] pyridine-4,3 '-indoline; solvent-free; green synthesis; MAMMALIAN-CELL CYCLE; ASPERGILLUS-FUMIGATUS; EFFICIENT SYNTHESIS; INHIBITORS;

D O I：

10.1007/s12039-013-0422-x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and efficient synthesis of spiro[pyrazolo[3,4-b]pyridine-4,3'-indoline] and spiro[benzo[h] pyrazolo[3,4-b]quinoline-4,3'-indoline] derivatives has been accomplished by the one-pot condensation of isatins, 3-methyl-1-phenyl-1H-pyrazol-5- amine and Meldrum's acid or 2-hydroxy-1,4-naphthoquinone in the presence of wet cyanuric chloride as a catalyst under solvent-free conditions.

引用

页码：601 / 606

页数：6

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