Synthesis of spiro[pyrazolo[3,4-b] pyridine-4,3′-indoline] and spiro [benzo[h]pyrazolo[3,4-b]quinoline-4,3′-indoline] derivatives using wet cyanuric chloride under solvent-free conditions

被引：12
|
作者：
Yin, Zhikui [1 ]
Yang, Limin [1 ]
Wu, Liqiang [1 ]
机构：
[1] Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China
来源：
JOURNAL OF CHEMICAL SCIENCES | 2013年 / 125卷 / 03期
关键词：
Cyanuric chloride; spiro[benzo[h]pyrazolo[3,4-b]quinoline-4,3 '-indoline; spiro[pyrazolo[3,4-b] pyridine-4,3 '-indoline; solvent-free; green synthesis; MAMMALIAN-CELL CYCLE; ASPERGILLUS-FUMIGATUS; EFFICIENT SYNTHESIS; INHIBITORS;
D O I：
10.1007/s12039-013-0422-x
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple and efficient synthesis of spiro[pyrazolo[3,4-b]pyridine-4,3'-indoline] and spiro[benzo[h] pyrazolo[3,4-b]quinoline-4,3'-indoline] derivatives has been accomplished by the one-pot condensation of isatins, 3-methyl-1-phenyl-1H-pyrazol-5- amine and Meldrum's acid or 2-hydroxy-1,4-naphthoquinone in the presence of wet cyanuric chloride as a catalyst under solvent-free conditions.
引用
收藏
页码：601 / 606
页数：6
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