Metagenomic study of the viruses of African straw-coloured fruit bats: Detection of a chiropteran poxvirus and isolation of a novel adenovirus

被引:113
作者
Baker, Kate S. [1 ,2 ]
Leggett, Richard M. [3 ]
Bexfield, Nicholas H. [1 ]
Alston, Mark [3 ]
Daly, Gordon [1 ]
Todd, Shawn [4 ]
Tachedjian, Mary [4 ]
Holmes, Clare E. G. [4 ]
Crameri, Sandra [4 ]
Wang, Lin-Fa [4 ]
Heeney, Jonathan L. [1 ]
Suu-Ire, Richard [5 ,6 ]
Kellam, Paul [7 ]
Cunningham, Andrew A. [2 ]
Wood, James L. N. [1 ]
Caccamo, Mario [3 ]
Murcia, Pablo R. [8 ]
机构
[1] Univ Cambridge, Dept Vet Med, Cambridge CB3 0ES, England
[2] Zool Soc London, Inst Zool, London NW1 4RY, England
[3] Genome Anal Ctr, Norwich NR4 7UH, Norfolk, England
[4] CSIRO Australian Anim Hlth Labs, East Geelong, Vic 3219, Australia
[5] Forestry Commiss, Wildlife Div, Accra, Ghana
[6] Univ Ghana, Noguchi Mem Inst Med Res, Legon, Accra, Ghana
[7] Wellcome Trust Sanger Inst, Hinxton CB101, Cambs, England
[8] Univ Glasgow, MRC, Coll Med Vet & Life Sci, Inst Infect Immun & Inflammat,Ctr Virus Res, Glasgow G61 1QH, Lanark, Scotland
基金
英国惠康基金; 英国生物技术与生命科学研究理事会;
关键词
Virome; Bat; Megabat; Poxvirus; Viral emergence; Metagenomics; Adenovirus; MULTIPLE SEQUENCE ALIGNMENT; GENETIC DIVERSITY; PREVALENCE; CORONAVIRUSES; EMERGENCE; INFECTION; PATHOGENS; ASSEMBLER; VIROME; RNA;
D O I
10.1016/j.virol.2013.03.014
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Viral emergence as a result of zoonotic transmission constitutes a continuous public health threat. Emerging viruses such as SARS coronavirus, hantaviruses and henipaviruses have wildlife reservoirs. Characterising the viruses of candidate reservoir species in geographical hot spots for viral emergence is a sensible approach to develop tools to predict, prevent, or contain emergence events. Here, we explore the viruses of Eidolon helvum, an Old World fruit bat species widely distributed in Africa that lives in close proximity to humans. We identified a great abundance and diversity of novel herpes and papilloma-viruses, described the isolation of a novel adenovirus, and detected, for the first time, sequences of a chiropteran poxvirus closely related with Molluscum contagiosum. In sum, E. helvum display a wide variety of mammalian viruses, some of them genetically similar to known human pathogens, highlighting the possibility of zoonotic transmission. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:95 / 106
页数:12
相关论文
共 53 条
  • [1] A virus discovery method incorporating DNase treatment and its application to the identification of two bovine parvovirus species
    Allander, T
    Emerson, SU
    Engle, RE
    Purcell, RH
    Bukh, J
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (20) : 11609 - 11614
  • [2] BASIC LOCAL ALIGNMENT SEARCH TOOL
    ALTSCHUL, SF
    GISH, W
    MILLER, W
    MYERS, EW
    LIPMAN, DJ
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1990, 215 (03) : 403 - 410
  • [3] The role of evolution in the emergence of infectious diseases
    Antia, R
    Regoes, RR
    Koella, JC
    Bergstrom, CT
    [J]. NATURE, 2003, 426 (6967) : 658 - 661
  • [4] Co-circulation of diverse paramyxoviruses in an urban African fruit bat population
    Baker, K. S.
    Todd, S.
    Marsh, G.
    Fernandez-Loras, A.
    Suu-Ire, R.
    Wood, J. L. N.
    Wang, L. F.
    Murcia, P. R.
    Cunningham, A. A.
    [J]. JOURNAL OF GENERAL VIROLOGY, 2012, 93 : 850 - 856
  • [5] Bermingham A, 2012, EUROSURVEILLANCE, V17, P6
  • [6] Novel astroviruses in insectivorous bats
    Chu, D. K. W.
    Poon, L. L. M.
    Guan, Y.
    Peiris, J. S. M.
    [J]. JOURNAL OF VIROLOGY, 2008, 82 (18) : 9107 - 9114
  • [7] Cleaveland S, 2007, CURR TOP MICROBIOL, V315, P85
  • [8] Establishment, Immortalisation and Characterisation of Pteropid Bat Cell Lines
    Crameri, Gary
    Todd, Shawn
    Grimley, Samantha
    McEachern, Jennifer A.
    Marsh, Glenn A.
    Smith, Craig
    Tachedjian, Mary
    De Jong, Carol
    Virtue, Elena R.
    Yu, Meng
    Bulach, Dieter
    Liu, Jun-Ping
    Michalski, Wojtek P.
    Middleton, Deborah
    Field, Hume E.
    Wang, Lin-Fa
    [J]. PLOS ONE, 2009, 4 (12):
  • [9] Metagenomic analysis of the turkey gut RNA virus community
    Day, J. Michael
    Ballard, Linda L.
    Duke, Mary V.
    Scheffler, Brian E.
    Zsak, Laszlo
    [J]. VIROLOGY JOURNAL, 2010, 7
  • [10] Viral genome sequencing by random priming methods
    Djikeng, Appolinaire
    Halpin, Rebecca
    Kuzmickas, Ryan
    DePasse, Jay
    Feldblyum, Jeremy
    Sengamalay, Naomi
    Afonso, Claudio
    Zhang, Xinsheng
    Anderson, Norman G.
    Ghedin, Elodie
    Spiro, David J.
    [J]. BMC GENOMICS, 2008, 9 (1)