DNA helicases involved in DNA repair and their roles in cancer

被引：254
|
作者：
Brosh, Robert M., Jr. [1 ]
机构：
[1] NIA, NIH, NIH Biomed Res Ctr, Lab Mol Gerontol, Baltimore, MD 21224 USA
来源：
NATURE REVIEWS CANCER | 2013年 / 13卷 / 08期
基金：
美国国家卫生研究院;
关键词：
WERNER-SYNDROME PROTEIN; ANEMIA GROUP J; BLOOMS-SYNDROME HELICASE; SYNDROME GENE-PRODUCT; HUMAN RECQ1 HELICASE; PIGMENTOSUM GROUP-D; RNA-POLYMERASE-II; CROSS-LINK REPAIR; FANCONI-ANEMIA; HOMOLOGOUS RECOMBINATION;
D O I：
10.1038/nrc3560
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Helicases have major roles in genome maintenance by unwinding structured nucleic acids. Their prominence is marked by various cancers and genetic disorders that are linked to helicase defects. Although considerable effort has been made to understand the functions of DNA helicases that are important for genomic stability and cellular homeostasis, the complexity of the DNA damage response leaves us with unanswered questions regarding how helicase-dependent DNA repair pathways are regulated and coordinated with cell cycle checkpoints. Further studies may open the door to targeting helicases in order to improve cancer treatments based on DNA-damaging chemotherapy or radiation.
引用
收藏
页码：542 / 558
页数：17
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