DNA helicases involved in DNA repair and their roles in cancer

被引：254
|
作者：
Brosh, Robert M., Jr. [1 ]
机构：
[1] NIA, NIH, NIH Biomed Res Ctr, Lab Mol Gerontol, Baltimore, MD 21224 USA
来源：
NATURE REVIEWS CANCER | 2013年 / 13卷 / 08期
基金：
美国国家卫生研究院;
关键词：
WERNER-SYNDROME PROTEIN; ANEMIA GROUP J; BLOOMS-SYNDROME HELICASE; SYNDROME GENE-PRODUCT; HUMAN RECQ1 HELICASE; PIGMENTOSUM GROUP-D; RNA-POLYMERASE-II; CROSS-LINK REPAIR; FANCONI-ANEMIA; HOMOLOGOUS RECOMBINATION;
D O I：
10.1038/nrc3560
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Helicases have major roles in genome maintenance by unwinding structured nucleic acids. Their prominence is marked by various cancers and genetic disorders that are linked to helicase defects. Although considerable effort has been made to understand the functions of DNA helicases that are important for genomic stability and cellular homeostasis, the complexity of the DNA damage response leaves us with unanswered questions regarding how helicase-dependent DNA repair pathways are regulated and coordinated with cell cycle checkpoints. Further studies may open the door to targeting helicases in order to improve cancer treatments based on DNA-damaging chemotherapy or radiation.
引用
收藏
页码：542 / 558
页数：17
相关论文
共 50 条
  • [21] DNA HELICASES
    KUHN, B
    ABDELMONEM, M
    HOFFMANNBERLING, H
    COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1979, 43 : 63 - 67
  • [22] DNA HELICASES
    MATSON, SW
    KAISERROGERS, KA
    ANNUAL REVIEW OF BIOCHEMISTRY, 1990, 59 : 289 - 329
  • [23] DNA polymerases β and λ and their roles in DNA replication and repair
    E. A. Belousova
    O. I. Lavrik
    Molecular Biology, 2010, 44 : 839 - 855
  • [24] DNA polymerases β and λ and their roles in DNA replication and repair
    Belousova, E. A.
    Lavrik, O. I.
    MOLECULAR BIOLOGY, 2010, 44 (06) : 839 - 855
  • [25] The role of genes involved in DNA repair in colorectal cancer
    Shorto, J
    Smith, G
    Waxman, R
    Katory, M
    Fletcher, D
    Meuth, M
    Bishop, T
    Cox, A
    JOURNAL OF MEDICAL GENETICS, 2003, 40 : S64 - S64
  • [26] 2 RELATED SUPERFAMILIES OF PUTATIVE HELICASES INVOLVED IN REPLICATION, RECOMBINATION, REPAIR AND EXPRESSION OF DNA AND RNA GENOMES
    GORBALENYA, AE
    KOONIN, EV
    DONCHENKO, AP
    BLINOV, VM
    NUCLEIC ACIDS RESEARCH, 1989, 17 (12) : 4713 - 4730
  • [27] Molecular analyses of DNA helicases involved in the replicational stress response
    Wu, Yuliang
    Sommers, Joshua A.
    Suhasini, Avvaru N.
    Aggarwal, Monika
    Brosh, Robert M.
    METHODS, 2010, 51 (03) : 303 - 312
  • [28] Molecular wrench activity of DNA helicases: Keys to modulation of rapid kinetics in DNA repair
    Wettasinghe, Ashan P.
    Seifi, Melodee O.
    Bravo, Marco
    Adams, Austen C.
    Patel, Aman
    Lou, Monica
    Kahanda, Dimithree
    Peng, Hao-Che
    Stelling, Allison L.
    Fan, Li
    Slinker, Jason D.
    PROTEIN SCIENCE, 2023, 32 (12)
  • [29] The roles of the eukaryotic DNA polymerases in DNA repair synthesis
    Budd, ME
    Campbell, JL
    MUTATION RESEARCH-DNA REPAIR, 1997, 384 (03): : 157 - 167
  • [30] Recombination and its roles in DNA repair, cellular immortalization and cancer
    Masood A. Shammas
    Robert J. Shmookler Reis
    AGE, 1999, 22 : 71 - 88
12345