RNA editing enters the limelight in cancer

被引：12
作者：
Gallo, Angela [1 ]
机构：
[1] Bambino Gesu Childrens Hosp IRCCS, Rome, Italy
来源：
NATURE MEDICINE | 2013年 / 19卷 / 02期
关键词：
GENE; ADAR1;
D O I：
10.1038/nm.3072
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
There has been much focus on DNA mutations in tumorigenesis and tumor progression, but now a new study highlights a role for post-transcriptional changes in RNA in cancer. The authors show increased RNA editing of antizyme inhibitor 1 (AZIN1) in tumor tissues from patients with hepatocellular carcinoma and characterize a mechanism through which the expression of edited AZIN1 protein leads to increased cell proliferation (pages 209-216).
引用
收藏
页码：130 / 131
页数：2
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