Monocytes and macrophages in malaria: protection or pathology?

被引：117

作者：

Chua, Caroline Lin Lin ^{[1
]}

Brown, Graham ^{[1
,2
]}

Hamilton, John A. ^{[1
]}

Rogerson, Stephen ^{[1
,3
]}

Boeuf, Philippe ^{[1
,3
]}

机构：

[1] Univ Melbourne, Dept Med, Royal Melbourne Hosp, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Nossal Inst Global Hlth, Parkville, Vic 3052, Australia

[3] Royal Melbourne Hosp, Victorian Infect Dis Serv, Parkville, Vic 3050, Australia

来源：

TRENDS IN PARASITOLOGY | 2013年 / 29卷 / 01期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

FALCIPARUM-INFECTED ERYTHROCYTES; RESPIRATORY-DISTRESS-SYNDROME; FC-GAMMA RECEPTOR; SYSTEMIC-LUPUS-ERYTHEMATOSUS; INNATE IMMUNE-RESPONSE; ACUTE LUNG INJURY; PLASMODIUM-FALCIPARUM; IN-VITRO; CEREBRAL MALARIA; PLACENTAL MALARIA;

D O I：

10.1016/j.pt.2012.10.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Recruitment and activation of monocytes and macrophages are essential for clearance of malaria infection, but these have also been associated with adverse clinical outcomes. In this review we discuss recent discoveries on how distinct molecular interactions between monocytes, macrophages, and malaria parasites may alter the balance between protection and pathology in malaria-infected individuals. The immunopathology of severe malaria often originates from excessive immune activation by parasites. The involvement of monocytes and macrophages in these events is highlighted, and priorities for future research to clarify the roles of these cells in malaria are proposed. Knowledge of the factors influencing the balance between protection and pathology can assist in the design of therapeutics aimed at modulating monocyte and macrophage functions to improve outcomes.

引用

页码：26 / 34

页数：9

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