Synthesis, Characterization, and Antibacterial Studies of Pd(II) and Pt(II) Complexes of Some Diaminopyrimidine Derivatives

被引：37

作者：

Ajibade, Peter A. ^{[1
]}

Idemudia, Omoruyi G. ^{[1
]}

机构：

[1] Univ Ft Hare, Dept Chem, ZA-5700 Alice, South Africa

来源：

BIOINORGANIC CHEMISTRY AND APPLICATIONS | 2013年 / 2013卷

关键词：

IN-VITRO ANTIPROTOZOAL; METAL-COMPLEXES; ANTIMALARIAL; VANADIUM; CRYSTAL; AGENT; TRIMETHOPRIM; ANTICANCER; MANAGEMENT; THERAPY;

D O I：

10.1155/2013/549549

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pd(II) and Pt(II) complexes of trimethoprimand pyrimethamine were synthesized and characterized by elemental analysis, UV-Vis, FTIR, and NMR spectroscopy. The complexes are formulated as four coordinate square planar species containing two molecules of the drugs and two chloride or thiocyanate ions. The coordination of the metal ions to the pyrimidine nitrogen atom of the drugs was confirmed by spectroscopic analyses. The complexes were screened for their antibacterial activities against eight bacterial isolates. They showed varied activities with the active metal complexes showing more enhanced inhibition than either trimethoprim or pyrimethamine. The Pd(II) complexes of pyrimethamine showed unique inhibitory activities against P. aeruginosa and B. pumilus, and none of the other complexes or the drugs showed any activity against these bacteria isolates. The MIC and MBC determinations revealed that these Pd(II) complexes are the most active. Structure activity relationship showed that Pt(II) complexes containing chloride ions are more active, while for Pd(II) complexes containing thiocyanate ions showed more enhanced activity than those containing chloride ions.

引用

页数：8

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