FEM-based numerical simulation supporting experimentally tested Electrochemotherapy protocols

被引：0
作者：
Lamberti, Patrizia [1 ]
Tucci, Vincenzo [1 ]
Romeo, Stefania [2 ]
Sannino, Anna [2 ]
Zeni, Olga [2 ]
Scarfi, Maria Rosaria [2 ]
机构：
[1] Univ Salerno, Dept Informat & Elect Engn & Appl Math, Salerno, Italy
[2] Italian Natl Res Council, Inst Electromagnet Sensing Environm, Naples, Italy
来源：
2017 14TH INTERNATIONAL CONFERENCE ON SYNTHESIS, MODELING, ANALYSIS AND SIMULATION METHODS AND APPLICATIONS TO CIRCUIT DESIGN (SMACD) | 2017年
关键词：
electroporation; ECT; electrophysiological model; time domain analysis; FEM; pulsed electric field; ELECTROPORATION;
D O I：
暂无
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
Electrochemotherapy (ECT) is a clinical procedure for the local treatment of solid tumors, which combines the application of pulsed electric fields (PEFs) and chemotherapeutic drugs, by exploiting the PEF-induced membrane permeabilization (electroporation, EP). The ESOPE pulsing protocol (8 pulses with 100 mu s duration and 1 kV/cm electric field strength, given at 1 Hz or 5 kHz as repetition rate) is the only protocol approved for application on human patients and is currently used in the clinical practice. Moving from an experimental study comparing the efficacy of ESOPE to that of modified PEF protocol with lower electric field intensity and higher pulse number, in this paper an electrophysiological model is used to provide theoretical support to the experimental results. The pore density and the transmembrane voltage time behavior at the upper pole of a single spherical cell are considered, in order to assess the EP effect of the applied pulse train, considered as boundary condition in the field based solution of the problem. The simulation results highlight that, 40 pulses 750 V/cm is a good candidate as ESOPE equivalent protocol.
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页数：4
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