SLE;
regulatory T cell;
interleukin-2;
immunotherapy;
tolerance;
immune homeostasis;
systemic lupus erythematosus;
LOW-DOSE INTERLEUKIN-2;
RESPONSIVE ELEMENT MODULATOR;
T-CELLS;
AUTOIMMUNE-DISEASE;
SELF-TOLERANCE;
VIVO EXPANSION;
PRONE MICE;
EX-VIVO;
FOXP3;
EXPRESSION;
D O I:
10.1080/1744666X.2016.1199957
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Introduction: The pathogenesis of systemic lupus erythematosus (SLE) involves an acquired deficiency of the cytokine IL-2, an essential growth and survival factor for regulatory T cells (Treg), which play an important role in the control of autoimmunity in SLE. In contrast to currently available therapies that broadly suppress the immune system, low-dose IL-2 therapy in SLE aims to compensate the pre-existing IL-2 deficiency and thus to restore a physiological state, where Treg can regain their ability to efficiently counteract autoimmunity.Areas covered: Here we summarize key findings that led to the development of this novel therapeutic concept and will highlight the key rationales for the clinical translation of low-dose IL-2 therapy in SLE.Expert commentary: The concept of low-dose IL-2 therapy in SLE has evolved from pathophysiological findings and thus can be considered a selective biological treatment strategy in SLE. Preliminary results from phase I/II studies are promising by proving selective Treg expansion and by providing first evidence for the clinical efficacy of low-dose IL-2 therapy in SLE.
机构:
UNIFESP, Discipline Reumatol, Div Rheumatol, BR-04023900 Sao Paulo, BrazilUNIFESP, Discipline Reumatol, Div Rheumatol, BR-04023900 Sao Paulo, Brazil
机构:
Univ Estadual Campinas, Fac Med Sci, Dept Med, Rheumatol Unit, BR-13083887 Campinas, SP, BrazilUniv Estadual Campinas, Fac Med Sci, Dept Med, Rheumatol Unit, BR-13083887 Campinas, SP, Brazil
Postal, Mariana
Costallat, Lilian T. L.
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机构:
Univ Estadual Campinas, Fac Med Sci, Dept Med, Rheumatol Unit, BR-13083887 Campinas, SP, BrazilUniv Estadual Campinas, Fac Med Sci, Dept Med, Rheumatol Unit, BR-13083887 Campinas, SP, Brazil
Costallat, Lilian T. L.
Appenzeller, Simone
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机构:
Univ Estadual Campinas, Fac Med Sci, Dept Med, Rheumatol Unit, BR-13083887 Campinas, SP, BrazilUniv Estadual Campinas, Fac Med Sci, Dept Med, Rheumatol Unit, BR-13083887 Campinas, SP, Brazil