Necrotizing Soft-Tissue Infections

被引:7
作者
Mullangi, Praveen K. [1 ]
Khardori, Nancy Misri [2 ]
机构
[1] Springfield Clin, Div Infect Dis, Springfield, IL 62701 USA
[2] Eastern Virginia Med Sch, Div Infect Dis, Dept Internal Med, Norfolk, VA 23501 USA
关键词
Fasciitis; Myonecrosis; Flesh eating bacteria; Soft-tissue infection; CLOSTRIDIAL GAS-GANGRENE; AEROMONAS-HYDROPHILA; CLINICAL-FEATURES; FASCIITIS; SKIN; MORTALITY; DIAGNOSIS;
D O I
10.1016/j.mcna.2012.08.003
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Soft-tissue infections encompass a wide spectrum of presentations ranging from superficial skin infection (cellulitis) to deep-seated infection (myositis and fasciitis), based on the depth and the area of involvement. Although less frequent, necrotizing soft-tissue infections (NSTIs) occur based on the interactions between the host factors and the causative pathogens. NSTIs are rapidly progressing and aggressive infections that can be lethal, with high morbidity and mortality. This article reviews some of the causative agents of NSTIs, clinical features, and the need for high index of suspicion for early recognition and prompt surgical and medical management.
引用
收藏
页码:1193 / +
页数:11
相关论文
共 38 条
[1]   Predictors of mortality and limb loss in necrotizing soft tissue infections [J].
Anaya, DA ;
McMahon, K ;
Nathens, AB ;
Sullivan, SR ;
Foy, H ;
Bulger, E .
ARCHIVES OF SURGERY, 2005, 140 (02) :151-157
[2]   Necrotizing soft-tissue infection: Diagnosis and management [J].
Anaya, Daniel A. ;
Dellinger, E. Patchen .
CLINICAL INFECTIOUS DISEASES, 2007, 44 (05) :705-710
[3]   Massive infectious soft-tissue injury: Diagnosis and management of necrotizing fasciitis and purpura fulminans [J].
Andreasen, TJ ;
Green, SD ;
Childers, BJ .
PLASTIC AND RECONSTRUCTIVE SURGERY, 2001, 107 (04) :1025-1034
[4]   VIRULENCE STUDIES ON CHROMOSOMAL ALPHA-TOXIN AND THETA-TOXIN MUTANTS CONSTRUCTED BY ALLELIC EXCHANGE PROVIDE GENETIC-EVIDENCE FOR THE ESSENTIAL ROLE OF ALPHA-TOXIN IN CLOSTRIDIUM PERFRINGENS-MEDIATED GAS-GANGRENE [J].
AWAD, MM ;
BRYANT, AE ;
STEVENS, DL ;
ROOD, JI .
MOLECULAR MICROBIOLOGY, 1995, 15 (02) :191-202
[5]   Current concepts - Streptococcal infections of skin and soft tissues [J].
Bisno, AL ;
Stevens, DL .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (04) :240-245
[6]   Clostridial gas gangrene.: I.: Cellular and molecular mechanisms of microvascular dysfunction induced by exotoxins of Clostridium perfringens [J].
Bryant, AE ;
Chen, RYZ ;
Nagata, Y ;
Wang, Y ;
Lee, CH ;
Finegold, S ;
Guth, PH ;
Stevens, DL .
JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (03) :799-807
[7]   Clostridial gas gangrene.: II.: Phospholipase C-induced activation of platelet gpIIbIIIa mediates vascular occlusion and myonecrosis in Clostridium perfringens gas gangrene [J].
Bryant, AE ;
Chen, RYZ ;
Nagata, Y ;
Wang, Y ;
Lee, CH ;
Finegold, S ;
Guth, PH ;
Stevens, DL .
JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (03) :808-815
[8]  
Cellulitis Swartz N., 2004, NEW ENGL J MED, V350, P9
[9]   Necrotizing soft-tissue infections [J].
Chapnick, EK ;
Abter, EI .
INFECTIOUS DISEASE CLINICS OF NORTH AMERICA, 1996, 10 (04) :835-+
[10]  
Childers BJ, 2002, AM SURGEON, V68, P109