Antidepressant Action on Mitochondrial Dysfunction in Psychiatric Disorders

被引：43

作者：

Adzic, Miroslav ^{[1
]}

Brkic, Zeljka ^{[1
]}

Bulajic, Sonja ^{[2
]}

Mitic, Milos ^{[1
]}

Radojcic, Marija B. ^{[1
]}

机构：

[1] Univ Belgrade, VINCA Inst Nucl Sci, Lab Mol Biol & Endocrinol, Belgrade, Serbia

[2] Univ Pristina, Sch Med, Kosovska Mitrovica, Serbia

来源：

DRUG DEVELOPMENT RESEARCH | 2016年 / 77卷 / 07期

关键词：

mitochondria; psychiatric disorders; antidepressants; intracellular signaling; brain energy metabolism; GLUCOCORTICOID-RECEPTOR PHOSPHORYLATION; RAT-BRAIN MITOCHONDRIA; ENERGY-METABOLISM; BIPOLAR DISORDER; EXPERIMENTAL-MODEL; RESPIRATORY-CHAIN; AMPK ACTIVATION; STRESSED RATS; DEPRESSION; FLUOXETINE;

D O I：

10.1002/ddr.21332

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mitochondria are cell organelles crucial to the production of cellular energy. Several lines of evidence have indicated that mitochondrial dysfunction could be related to the pathophysiology of CNS diseases including bipolar disorder, major depressive disorder, and schizophrenia. These changes include impaired energy metabolism in the brain, co-morbidity with mitochondrial diseases, the effects of psychotropics on mitochondrial function, increased mitochondrial DNA (mtDNA) deletion in the brain, and association with mtDNA polymorphisms. Additionally, psychotropic drug treatments can alter energy metabolism and may affect mitochondrial processes. This review focuses on recent findings regarding the effects of antidepressants on mitochondrial processes in psychiatric disorders. Drug Dev Res 77 : 400-406, 2016. (c) 2016 Wiley Periodicals, Inc.

引用

页码：400 / 406

页数：7

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