Post-Translational Modifications by Lipid Metabolites during the DNA Damage Response and Their Role in Cancer

被引：3

作者：

Zhu, Guangrong ^{[1
,2
]}

Zheng, Xiangyang ^{[3
]}

Wang, Zhifeng ^{[1
]}

Xu, Xingzhi ^{[1
]}

机构：

[1] Shenzhen Univ, Guangdong Key Lab Genome Stabil & Dis Prevent, Carson Int Canc Ctr, Marshall Lab Biomed Engn,Sch Med, Shenzhen 518060, Peoples R China

[2] Shenzhen Univ, Guangdong Key Lab Biomed Measurements & Ultrasoun, Sch Biomed Engn, Sch Med, Shenzhen 518060, Peoples R China

[3] Dehua Hosp, Shenzhen Univ Gen Hosp Dehua Hosp Joint Res Ctr P, Quanzhou 362500, Peoples R China

来源：

BIOMOLECULES | 2022年 / 12卷 / 11期

基金：

中国国家自然科学基金;

关键词：

DNA damage response; post-translational modification; lipid metabolites; acetylation; S-succinylation; palmitoylation; N-myristoylation; crotonylation; cancer; PYRUVATE-KINASE M2; HISTONE CROTONYLATION; YEATS DOMAIN; SELECTIVE-INHIBITION; LYSINE CROTONYLATION; ACETYLATION; REPAIR; TIP60; ACTIVATION; CHROMATIN;

D O I：

10.3390/biom12111655

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genomic DNA damage occurs as an inevitable consequence of exposure to harmful exogenous and endogenous agents. Therefore, the effective sensing and repair of DNA damage are essential for maintaining genomic stability and cellular homeostasis. Inappropriate responses to DNA damage can lead to genomic instability and, ultimately, cancer. Protein post-translational modifications (PTMs) are a key regulator of the DNA damage response (DDR), and recent progress in mass spectrometry analysis methods has revealed that a wide range of metabolites can serve as donors for PTMs. In this review, we will summarize how the DDR is regulated by lipid metabolite-associated PTMs, including acetylation, S-succinylation, N-myristoylation, palmitoylation, and crotonylation, and the implications for tumorigenesis. We will also discuss potential novel targets for anti-cancer drug development.

引用

页数：27

共 217 条

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