Increased Contact System Activation in Mild Cognitive Impairment Patients with Impaired Short-Term Memory

被引：13

作者：

Singh, Pradeep K. ^{[1
]}

Chen, Zu-Lin ^{[1
]}

Strickland, Sidney ^{[1
]}

Norris, Erin H. ^{[1
]}

机构：

[1] Rockefeller Univ, Patricia & John Rosenwald Lab Neurobiol & Genet, New York, NY 10065 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2020年 / 77卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Alzheimer's disease; bradykinin; contact activation; high molecular weight kininogen; memory impairment; mild cognitive impairment; plasma kallikrein; BLOOD-BRAIN-BARRIER; ALZHEIMERS-DISEASE; FACTOR-XII; COAGULATION; HYPOMETABOLISM; BRADYKININ; FIBRINOGEN; DECLINE; INHIBITION; PREDICTORS;

D O I：

10.3233/JAD-200343

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

An activated plasma contact system is an abnormality observed in many Alzheimer's disease (AD) patients. Since mild cognitive impairment (MCI) patients often develop AD, we analyzed the status of contact system activation in MCI patients. We found that kallikrein activity, high molecular weight kininogen cleavage, and bradykinin levels-measures of contact system activation-were significantly elevated in MCI patient plasma compared to plasma from ageand education matched healthy individuals. Changes were more pronounced in MCI patients with impaired short-term recall memory, indicating the possible role of the contact system in early cognitive changes.

引用

页码：59 / 65

页数：7

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