Parkinson's disease and immune system: is the culprit LRRKing in the periphery?

被引：30

作者：

Greggio, Elisa ^{[1
]}

Civiero, Laura ^{[1
]}

Bisaglia, Marco ^{[1
]}

Bubacco, Luigi ^{[1
]}

机构：

[1] Univ Padua, Dept Biol, I-35121 Padua, Italy

来源：

JOURNAL OF NEUROINFLAMMATION | 2012年 / 9卷

关键词：

Parkinson's disease; Leucine-rich repeat kinase 2 (LRRK2); Neuroinflammation; Cytokines; REPEAT KINASE 2; TUMOR-NECROSIS-FACTOR; BLOOD-BRAIN-BARRIER; GENOME-WIDE ASSOCIATION; ALPHA-SYNUCLEIN; INTERFERON-GAMMA; CEREBROSPINAL-FLUID; R1441C MUTATION; 14-3-3; BINDING; ROC DOMAIN;

D O I：

10.1186/1742-2094-9-94

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Leucine-rich repeat kinase 2 (LRRK2) is a large multidomain kinase/GTPase that has been recently linked to three pathological conditions: Parkinson's disease; Crohn's disease; and leprosy. Although LRRK2 physiological function is poorly understood, a potential role in inflammatory response is suggested by its high expression in immune cells and tissues, its up-regulation by interferon., and its function as negative regulator of the immune response transcription factor NFAT1. In this review we discuss the most recent findings regarding how LRRK2 could be a player in the inflammatory response and we propose a scenario where the detrimental effects mediated by Parkinson's disease LRRK2 mutations may initiate in the periphery and extend to the central nervous system as a consequence of increased levels of pro-inflammatory factors permeable to the blood brain barrier.

引用

页数：7

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