Up-regulation of microRNA-210 induces immune dysfunction via targeting FOXP3 in CD4+ T cells of psoriasis vulgaris

被引：147

作者：

Zhao, Ming ^{[1
]}

Wang, Li-tao ^{[1
]}

Liang, Gong-ping ^{[1
]}

Zhang, Peng ^{[1
]}

Deng, Xin-jie ^{[1
]}

Tang, Qian ^{[1
]}

Zhai, Han-yue ^{[1
]}

Chang, Christopher C. ^{[2
]}

Su, Yu-wen ^{[1
]}

Lu, Qian-jin ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Hosp 2, Dept Dermatol, Hunan Key Lab Med Epigen, Changsha 410011, Hunan, Peoples R China

[2] Thomas Jefferson Univ Hosp, Dept Pediat, Div Allergy Asthma & Immunol, Philadelphia, PA 19107 USA

来源：

CLINICAL IMMUNOLOGY | 2014年 / 150卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Psoriasis vulgaris CD4(+) T cells; MicroRNA; FOXP3; Treg cells; miR-210; EXPRESSION; IDENTIFICATION; PROLIFERATION; PATHOGENESIS; ACTIVATION; MECHANISMS; CYTOKINES; HYPOXIA; CANCER; BLOOD;

D O I：

10.1016/j.clim.2013.10.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Psoriasis vulgaris (PV) is a chronic inflammatory and T cell-mediated autoimmune skin disease. An immune dysfunction that is manifested by abnormally activated T cells and defective regulatory T (Treg) cells may play an important role in the pathogenesis of PV. However, the precise mechanism of the immune dysfunction in PV patients still remains unclear. In this study, we found that miR-210 expression is increased significantly in CD4(+) T cells from patients with PV and confirmed that FOXP3 is a target gene of miR-210. We also found that overexpression of miR-210 inhibits FOXP3 expression and impairs the immunosuppressive functions of Treg cells in CD4(+) T cells from healthy controls. In contrast, inhibition of miR-210 increases FOXP3 expression and reverses the immune dysfunction in CD4(+) T cells from patients with PV. Our data demonstrates that increased miR-210 induces immune dysfunction via by FOXP3 in CD4(+) T cells from patients with PV. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：22 / 30

页数：9

共 42 条

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