Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling

被引：364

作者：

Crane, Janet L. ^{[1
,2
]}

Cao, Xu ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Orthopaed Surg, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2014年 / 124卷 / 02期

关键词：

GROWTH-FACTOR-BETA; CAMURATI-ENGELMANN-DISEASE; LATENCY-ASSOCIATED PEPTIDE; DOMAIN-SPECIFIC MUTATIONS; PARATHYROID-HORMONE; TRANSFORMING GROWTH-FACTOR-BETA-1; FACTOR-I; OSTEOBLASTIC CELLS; ANABOLIC ACTIVITY; OXIDATIVE STRESS;

D O I：

10.1172/JCI70050

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

During bone resorption, abundant factors previously buried in the bone matrix are released into the bone marrow microenvironment, which results in recruitment and differentiation of bone marrow mesenchymal stem cells (MSCs) for subsequent bone formation, temporally and spatially coupling bone remodeling. Parathyroid hormone (PTH) orchestrates the signaling of many pathways that direct MSC fate. The spatiotemporal release and activation of matrix TGF-beta during osteoclast bone resorption recruits MSCs to bone-resorptive sites. Dysregulation of TGF-beta alters MSC fate, uncoupling bone remodeling and causing skeletal disorders. Modulation of TGF-beta or PTH signaling may reestablish coupled bone remodeling and be a potential therapy.

引用

页码：466 / 472

页数：7

共 118 条

[1] Targeting the TGFβ signalling pathway in disease [J].

Akhurst, Rosemary J. ;

Hata, Akiko .

NATURE REVIEWS DRUG DISCOVERY, 2012, 11 (10) :790-811

[2] TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation [J].

Alliston, T ;

Choy, L ;

Ducy, P ;

Karsenty, G ;

Derynck, R .

EMBO JOURNAL, 2001, 20 (09) :2254-2272

[3] Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids [J].

Almeida, Maria ;

Han, Li ;

Martin-Millan, Marta ;

Plotkin, Lilian I. ;

Stewart, Scott A. ;

Roberson, Paula K. ;

Kousteni, Stavroula ;

O'Brien, Charles A. ;

Bellido, Teresita ;

Parfitt, A. Michael ;

Weinstein, Robert S. ;

Jilka, Robert L. ;

Manolagas, Stavros C. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (37) :27285-27297

[4] Mice deficient in small leucine-rich proteoglycans:: novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseases [J].

Ameye, L ;

Young, MF .

GLYCOBIOLOGY, 2002, 12 (09) :107R-116R

[5] Signal transduction by the TGF-β superfamily [J].

Attisano, L ;

Wrana, JL .

SCIENCE, 2002, 296 (5573) :1646-1647

[6] TGF-β regulates the mechanical properties and composition of bone matrix [J].

Balooch, G ;

Balooch, M ;

Nalla, RK ;

Schilling, S ;

Filvaroff, EH ;

Marshall, GW ;

Marshall, SJ ;

Ritchie, RO ;

Derynck, R ;

Alliston, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (52) :18813-18818

[7] Vascular development: Cellular and molecular regulation [J].

Beck, L ;

DAmore, PA .

FASEB JOURNAL, 1997, 11 (05) :365-373

[8] Improving subchondral bone integrity reduces progression of cartilage damage in experimental osteoarthritis preceded by osteoporosis [J].

Bellido, M. ;

Lugo, L. ;

Roman-Blas, J. A. ;

Castaneda, S. ;

Calvo, E. ;

Largo, R. ;

Herrero-Beaumont, G. .

OSTEOARTHRITIS AND CARTILAGE, 2011, 19 (10) :1228-1236

[9] The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine [J].

Bianco, Paolo ;

Cao, Xu ;

Frenette, Paul S. ;

Mao, Jeremy J. ;

Robey, Pamela G. ;

Simmons, Paul J. ;

Wang, Cun-Yu .

NATURE MEDICINE, 2013, 19 (01) :35-42

[10] Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone [J].

Bikle, DD ;

Sakata, T ;

Leary, C ;

Elalieh, H ;

Ginzinger, D ;

Rosen, CJ ;

Beamer, W ;

Majumdar, S ;

Halloran, BP .

JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 (09) :1570-1578

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