IFR4/MUM1-positive lymphoma in Waldeyer ring with co-expression of CD5 and CD10

被引：18
作者：
Chen, Lei [1 ]
Al-Kzayer, Lika'a Fasih Y. [2 ]
Liu, Tingting [3 ]
Kobayashi, Norimoto [2 ]
Nakazawa, Yozo [2 ]
Koike, Kenichi [2 ]
机构：
[1] Shanghai Jiao Tong Univ, Dept Pathol, Xinhua Hosp, Sch Med, Shanghai, Peoples R China
[2] Shinshu Univ, Sch Med, Dept Pediat, Matsumoto, Nagano, Japan
[3] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Pediat Hematol, Shanghai, Peoples R China
来源：
PEDIATRIC BLOOD & CANCER | 2017年 / 64卷 / 02期
关键词：
CD5; IRF4/MUM1-positive lymphoma; pediatric follicular lymphoma; Waldeyer ring; CD5-POSITIVE FOLLICULAR LYMPHOMA; B-CELL LYMPHOMA; YOUNG-ADULTS; GRADE; 3B; CHILDREN; PROGNOSIS;
D O I：
10.1002/pbc.26236
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
IRF4/MUM1-positive lymphoma is a new subgroup of germinal center-derived B-cell lymphoma, predominantly involving the Waldeyer ring (WR) in children. CD5 expression is rare in these lymphomas. We report a 7-year-old Chinese male with B-cell lymphoma. Evaluation of his specimen by morphology, immunohistochemistry, and FISH analysis demonstrated IRF4/MUM1-positive lymphoma with strong and extensive CD5 and CD10 positivity. Despite the lack of t(14;18)(q32;q21) rearrangement, BCL2 protein was expressed. Our report highlights the clinicopathologic features of IFR4/MUM1-positive lymphoma in WR with co-expression of CD5 and CD10, and thereby provides insight into this newly recognized disease entity.
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收藏
页码：311 / 314
页数：4
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