Lipid Droplets as Immune Modulators in Myeloid Cells

被引：148

作者：

den Brok, Martijn H. ^{[1
,2
]}

Raaijmakers, Tonke K. ^{[1
,2
]}

Collado-Camps, Estel ^{[1
]}

Adema, Gosse J. ^{[1
]}

机构：

[1] Radboud UMC, Radboud Inst Mol Life Sci, Dept Radiat Oncol, Radiotherapy & OncoImmunol Lab, Geert Grootepl Zuid 32, NL-6525 GA Nijmegen, Netherlands

[2] Radboud UMC, Dept Anesthesiol Pain & Palliat Med, Geert Grootepl 10, NL-6525 GA Nijmegen, Netherlands

来源：

TRENDS IN IMMUNOLOGY | 2018年 / 39卷 / 05期

关键词：

ENDOPLASMIC-RETICULUM STRESS; UNFOLDED PROTEIN RESPONSE; ANTIGEN CROSS-PRESENTATION; DENDRITIC CELLS; ER STRESS; EICOSANOID SYNTHESIS; TRANSCRIPTION FACTOR; ANTITUMOR IMMUNITY; HEPATIC STEATOSIS; METABOLISM;

D O I：

10.1016/j.it.2018.01.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lipid droplets (LDs) were initially described as fat storage organelles in adipocytes, but are increasingly recognized as dynamic players in lipid metabolism, with important roles not only in diseases such as diabetes and cancer, but also in immune regulation. Alterations in immune cell function, such as myeloid cell activation, are connected to profound changes in LD numbers and LD protein composition. Thus, these organelles appear to be essential to metabolically support immune responses, and have a vital role in antigen cross-presentation, interferon (IFN) responses, production of inflammatory mediators, and pathogen clearance. Here, we review recent studies that report on the role of LDs in the modulation of immune cell function, primarily focusing on myeloid cells, such as macrophages and dendritic cells (DCs).

引用

页码：380 / 392

页数：13

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