Microtools for single-cell analysis in biopharmaceutical development and manufacturing

被引：44

作者：

Love, Kerry Routenberg ^{[1
]}

Bagh, Sangram ^{[2
]}

Choi, Jonghoon ^{[2
]}

Love, J. Christopher ^{[1
,2
]}

机构：

[1] MIT, David H Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA

[2] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2013年 / 31卷 / 05期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

microtools; biologic; microengraving; microwells; HIGH-THROUGHPUT; DYNAMICS; BACTERIA; TRIAL;

D O I：

10.1016/j.tibtech.2013.03.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Biologic drugs are promoting growth in the biopharmaceutical industry. Despite the clinical benefits of these drugs, the time and costs required to bring new biologics to market still are substantial. Three key challenges, among others, persist in the development of biologic drugs: namely, establishing product similarity, product toxicity, and global accessibility. New classes of microtools that facilitate the isolation and interrogation of single cells have the potential to impact each of these challenges. This opinion considers recent examples of microtools with demonstrated or potential utility to address problems in these areas. Integrating these advanced technologies into the development of new biologics could greatly reduce time and costs required to bring alternative products to market, and thus expand their global availability.

引用

页码：16 / 22

页数：7

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