Conditioned Pain Modulation: A Predictor for Development and Treatment of Neuropathic Pain

被引：57

作者：

Granovsky, Yelena ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Fac Med, Dept Neurol, Clin Neurophysiol Lab,Rambam Hlth Care Campus, Haifa, Israel

来源：

CURRENT PAIN AND HEADACHE REPORTS | 2013年 / 17卷 / 09期

关键词：

Central sensitization; Chronic pain; Conditioned pain modulation (CPM); Personalized pain medicine; Neuropathic pain; Pain facilitation; Pain inhibition; Psychophysics; NOXIOUS INHIBITORY CONTROLS; TENSION-TYPE HEADACHE; PREOPERATIVE EXPERIMENTAL PAIN; CHRONIC POSTOPERATIVE PAIN; POSTCESAREAN SECTION PAIN; IRRITABLE-BOWEL-SYNDROME; DORSAL-HORN; CONVERGENT NEURONS; PHARMACOLOGICAL-TREATMENT; SOMATOSENSORY PERCEPTION;

D O I：

10.1007/s11916-013-0361-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Psychophysical evaluation of endogenous pain inhibition via conditioned pain modulation (CPM) represents a new generation of laboratory tests for pain assessment. In this review we discuss recent findings on CPM in neuropathic pain and refer to psychophysical, neurophysiological, and methodological aspects of its clinical implications. Typically, chronic neuropathic pain patients express less efficient CPM, to the extent that incidence of acquiring neuropathic pain (e.g. post-surgery) and its intensity can be predicted by a pre-surgery CPM assessment. Moreover, pretreatment CPM evaluation may assist in the correct choice of serotonin-noradrenalin reuptake inhibitor analgesic agents for individual patients. Evaluation of pain modulation capabilities can serve as a step forward in individualizing pain medicine.

引用

页数：7

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