Boric Acid Catalyzed Convenient Synthesis of Benzimidazoles in Aqueous Media

被引：4

作者：

Heravi, Mohammad Reza Poor ^{[1
]}

Ashori, Marjan ^{[1
]}

机构：

[1] Payame Noor Univ, Dept Chem, Tehran 193954697, Iran

来源：

JOURNAL OF CHEMISTRY | 2013年 / 2013卷

关键词：

2-SUBSTITUTED BENZIMIDAZOLES; MICHAEL REACTIONS; ALDEHYDES; MICROWAVE;

D O I：

10.1155/2013/496413

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of benzimidazoles has been developed by the o-phenylenediamine with aldehydes using boric acid an efficient catalyst under mild reaction conditions in aqueous media. The product is applicable to aryl and heteroaryl aldehydes. This reaction led to the formation of benzimidazoles new derivatives in good yields. The FT-IR, F-19-NMR, H-1-NMR, C-13-NMR spectra and elemental analysis confirm the structure of compounds.

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页数：5

相关论文

共 31 条

[1]

Anisimova V.A., 2002, Pharm. Chem. J., V36, P377, DOI [10.1023/A:1021096114589, DOI 10.1023/A:1021096114589]

[2] A simple and efficient one-pot synthesis of 2-substituted benzimidazoles [J].

Bahrami, Kiumars ;

Khodaei, Mohammad Mehdi ;

Kavianinia, Iman .

SYNTHESIS-STUTTGART, 2007, (04) :547-550

[3]

Bai YJ, 2001, SYNLETT, P544

[4] Benzimidazoles: Oxidative heterocyclization via nitrobenzene and dimethylsufloxide on silica submitted to microwave or ultraviolet irradiation [J].

Ben-Alloum, A ;

Bakkas, S ;

Soufiaoui, M .

TETRAHEDRON LETTERS, 1998, 39 (25) :4481-4484

[5] HYDROPHOBIC EFFECTS ON SIMPLE ORGANIC-REACTIONS IN WATER [J].

BRESLOW, R .

ACCOUNTS OF CHEMICAL RESEARCH, 1991, 24 (06) :159-164

[6] A Simple, Mild, and Efficient Procedure for High-Yield Synthesis of Benzimidazoles Using Coppertriflate as Catalyst [J].

Chari, M. Adharvana ;

Sadanandam, P. ;

Shobha, D. ;

Mukkanti, K. .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 2010, 47 (01) :153-155

[7] Boric acid catalyzed thia-Michael reactions in water or alcohols [J].

Chaudhuri, Mihir K. ;

Hussain, Sahid .

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL, 2007, 269 (1-2) :214-217

[8] Boric acid: a novel and safe catalyst for aza-Michael reactions in water [J].

Chaudhuri, MK ;

Hussain, S ;

Kantam, ML ;

Neelima, B .

TETRAHEDRON LETTERS, 2005, 46 (48) :8329-8331

[9] POTENTIAL ANTITUMOR AGENTS .59. STRUCTURE-ACTIVITY-RELATIONSHIPS FOR 2-PHENYLBENZIMIDAZOLE-4-CARBOXAMIDES, A NEW CLASS OF MINIMAL DNA-INTERCALATING AGENTS WHICH MAY NOT ACT VIA TOPOISOMERASE-II [J].

DENNY, WA ;

REWCASTLE, GW ;

BAGULEY, BC .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (02) :814-819

[10] A short synthesis of phenanthro[2,3-d]imidazoles from dehydroabietic acid.: Application of the methodology as a convenient route to benzimidazoles [J].

Fonseca, T ;

Gigante, B ;

Gilchrist, TL .

TETRAHEDRON, 2001, 57 (09) :1793-1799

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